Bellamy has given two statements about what "Cave" is about. Once he said it was about "an old friend of mine" in a strangely warbled voice before a live performance of the song and on a different occasion he stated "The idea for Cave came from that rubbish American book, Men Are from Mars, Women Are from Venus. There's this bit about how men go into a cave when they get stressed and I think that's probably true, although, personally, I tend to let it out. I did have a bit of a tantrum in my hotel bathroom last night – but I managed to repair the toilet, so that's OK."
A piano version of this song was played during the Resistance Tour live performances, which marks the first time in eight years the song had been performed live. Matt Bellamy has stated he dislikes performing this song because of the extended word "Cave" during the chorus.