Caveolin 2

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Not to be confused with 2CAV, the 2nd Cavalry (disambiguation)
caveolin 2
Identifiers
Aliases CAV2, CAV, caveolin 2
External IDs MGI: 107571 HomoloGene: 942 GeneCards: 858
RNA expression pattern
PBB GE CAV2 203323 at tn.png

PBB GE CAV2 203324 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206747
NM_001206748
NM_001233
NM_198212

NM_001277756
NM_016900

RefSeq (protein)

NP_001193676.1
NP_001193677.1
NP_001224.1
NP_937855.1

NP_058596.1

Location (UCSC) Chr 7: 116.29 – 116.51 Mb Chr 6: 17.28 – 17.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.[1][2][3]

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.[3]

Interactions[edit]

Caveolin 2 has been shown to interact with Caveolin 1[4][5] and RAS p21 protein activator 1.[6]

References[edit]

  1. ^ Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, Lisanti MP (Feb 1996). "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family". Proc Natl Acad Sci U S A 93 (1): 131–5. doi:10.1073/pnas.93.1.131. PMC 40192. PMID 8552590. 
  2. ^ Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (May 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID 10087206. 
  3. ^ a b "Entrez Gene: CAV2 caveolin 2". 
  4. ^ Breuza, Lionel; Corby Séverine; Arsanto Jean-Pierre; Delgrossi Marie-Hélène; Scheiffele Peter; Le Bivic André (Dec 2002). "The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells". J. Cell. Sci. (England) 115 (Pt 23): 4457–67. doi:10.1242/jcs.00130. ISSN 0021-9533. PMID 12414992. 
  5. ^ Scherer, P E; Lewis R Y; Volonte D; Engelman J A; Galbiati F; Couet J; Kohtz D S; van Donselaar E; Peters P; Lisanti M P (Nov 1997). "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo". J. Biol. Chem. (UNITED STATES) 272 (46): 29337–46. doi:10.1074/jbc.272.46.29337. ISSN 0021-9258. PMID 9361015. 
  6. ^ Lee, Hyangkyu; Park David S; Wang Xiao Bo; Scherer Philipp E; Schwartz Phillip E; Lisanti Michael P (Sep 2002). "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1". J. Biol. Chem. (United States) 277 (37): 34556–67. doi:10.1074/jbc.M204367200. ISSN 0021-9258. PMID 12091389. 

Further reading[edit]