Cavicularin

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Cavicularin
Cavicularin.svg
Names
IUPAC name
9,10,18,19-Tetrahydro-5,8:15,17-diethenobenzo[g]naphth[1,8-bc]oxacyclotetradecin-3,12,21-triol
Identifiers
178734-41-3 YesY
ChemSpider 9491133 N
Jmol 3D model Interactive image
PubChem 11316166
Properties
C28H22O4
Molar mass 422.48 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Cavicularin is a natural phenolic secondary metabolite isolated from the liverwort Cavicularia densa. This macrocycle is unusual because it was the first compound isolated from nature displaying optical activity solely due to the presence of planar chirality and axial chirality. The specific rotation for (+)-cavicularin is +168.2°.[1] It is also a very strained molecule. The para-substituted phenol ring is bent about 15° out of planarity, adopting a somewhat boat-like geometry. This type of angle strain in aromatic compounds is normally reserved for synthetic cyclophanes.

Cavicularin, three-dimensional representation

The liverwort was obtained from Mount Ishizuchi in the district of Shikoku. The material was dried for one day, ground to a powder and 5 grams were refluxed in methanol for 4 months to yield 2.5 mg (0.049%) of cavicularin after column chromatography and preparative TLC.

Riccardin C, flat molecule representation

Total synthesis[edit]

In 2005 and again in 2011, the compound was prepared by total synthesis together with the unstrained compound riccardin C.[2][3] The strategy used was a radical reaction. In 2013 several procedures have been reported, one based on transannulation,[4] one based on a Diels-Alder reaction [5] and one (racemic) based on a coupling reaction.[6]

References[edit]

  1. ^ M. Toyota; T. Yoshida; Y. Kan; S. Takaoka; Y. Asakawa (1996). "(+)-Cavicularin: A Novel Optically Active Cyclic Bibenzyl-Dihydrophenanthrene Derivative from the Liverwort Cavicularia densa Steph". Tetrahedron Letters. 37 (27): 4745–4748. doi:10.1016/0040-4039(96)00956-2. 
  2. ^ David C. Harrowven; Timothy Woodcock; Peter D. Howes (2005). "Total Synthesis of Cavicularin and Riccardin C: Addressing the Synthesis of an Arene That Adopts a Boat Configuration". Angewandte Chemie. 44 (25): 3899–3901. doi:10.1002/anie.200500466. PMID 15900530. 
  3. ^ Kostiuk, S. L.; Woodcock, T.; Dudin, L. F.; Howes, P. D.; Harrowven, D. C. (2011). "Unified Syntheses of Cavicularin and Riccardin C: Addressing the Synthesis of an Arene Adopting a Boat Configuration". Chemistry: A European Journal. 17: 10906–10915. doi:10.1002/chem.201101550. 
  4. ^ Takiguchi, H.; Ohmori, K.; Suzuki, K. (2013). "Synthesis and Determination of the Absolute Configuration of Cavicularin by a Symmetrization/Asymmetrization Approach". Angew. Chem. Int. Ed. 52: 10472–10476. doi:10.1002/anie.201304929. 
  5. ^ Zhao, Peng; Beaudry, Christopher M. (2013). "Total Synthesis of (±)-Cavicularin: Control of Pyrone Diels–Alder Regiochemistry Using Isomeric Vinyl Sulfones". Organic Letters. 15 (2): 402–405. doi:10.1021/ol303390a. 
  6. ^ Harada, Kenichi; Makino, Kosho; Shima, Naoki; Okuyama, Haruka; Esumi, Tomoyuki; Kubo, Miwa; Hioki, Hideaki; Asakawa, Yoshinori; Fukuyama, Yoshiyasu (2013). "Total synthesis of riccardin C and (±)-cavicularin via Pd-catalyzed Ar–Ar cross couplings". Tetrahedron. 69 (34): 6959–6968. doi:10.1016/j.tet.2013.06.064.