Cayuga Creek runs through the Lancaster Country Club and Como Lake Park in the Town of Lancaster. The Lancaster Country Club diverts some creek water for golf course irrigation. In Como Lake Park, the creek is dammed upstream of Lake Avenue. Farther downstream the creek is an important feature in Stiglemeyer Park in the Town of Cheektowaga.
After Cayuga Creek flooded the Village of Lancaster twice in the early 1940s, protective dikes were constructed.