Cefazaflur

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Cefazaflur
Cefazaflur.png
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C13H13F3N6O4S3
Molar mass 470.470 g/mol
3D model (JSmol)
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Cefazaflur (INN) is a first-generation cephalosporin antibiotic.

Synthesis[edit]

Cefazaflur stands out among this group of analogues because it lacks an arylamide C-7 side chain (see cephacetrile for another example).

Cefazaflur synthesis:[1]

Cefazaflur is synthesized by reaction of 3-(1-methyl-1H-tetrazol-5-ylthiomethylene)-7-amino-cephem-4-carboxylic acid (1) with trifluoromethylthioacetyl chloride (2).

References[edit]

  1. ^ Demarinis, R. M.; Boehm, J. C.; Dunn, G. L.; Hoover, J. R. E.; Uri, J. V.; Guarini, J. R.; Phillips, L.; Actor, P.; Weisbach, J. A. (1977). "Semisynthetic cephalosporins. Synthesis and structure-activity relations of analogs with 7-acyl groups derived from 2-(cyanomethylthio)acetic acid or 2-[(2,2,2-trifluoroethyl)thio]acetic acid and their sulfoxides and sulfones". Journal of Medicinal Chemistry. 20 (1): 30–5. PMID 319233. doi:10.1021/jm00211a006.