Cefmetazole

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cefmetazole
Cefmetazole.svg
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a601206
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.054.877
Chemical and physical data
Formula C15H17N7O5S3
Molar mass 471.538 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.

Adverse effects[edit]

The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.[1]

Spectrum of bacterial susceptibility[edit]

Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Bacteroides fragilis: 0.06 - >256 µg/ml
  • Clostridium difficile: 8 - >128 µg/ml
  • Staphylococcus aureus: 0.5 - 256 µg/ml (includes MRSA)

[2]

References[edit]

  1. ^ Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA. Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03. 
  2. ^ http://www.toku-e.com/Assets/MIC/Cefmetazole%20free%20acid.pdf