SERPINA9

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SERPINA9
Identifiers
Aliases SERPINA9, GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDs MGI: 1919157 HomoloGene: 23633 GeneCards: SERPINA9
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042518
NM_001284275
NM_001284276
NM_175739

NM_027997

RefSeq (protein)

NP_001035983
NP_001271204
NP_001271205
NP_783866

NP_082273.1
NP_082273

Location (UCSC) Chr 14: 94.46 – 94.48 Mb Chr 12: 103.99 – 104.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[3] Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function[edit]

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[4][5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: SERPINA9". 
  4. ^ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310Freely accessible. PMID 17447896. 
  5. ^ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315. 
  6. ^ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480. 

Further reading[edit]

External links[edit]