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A centroblast generally refers to an activated B cell that is enlarged (12-18 micrometer) and proliferating in the germinal center of a secondary lymphoid follicle.[1] Centroblasts form following exposure to follicular dendritic cell cytokines, such as IL-6, IL-15, 8D6, and BAFF and stimulation from helper T cell interactions between their CD40 ligand and the B cell CD40 induces centroblasts to express activation-induced cytidine deaminase, leading to somatic hypermutation.

Centroblasts do not express immunoglobulins and are unable to respond to the follicular dendritic cell antigens present in the secondary lymphoid follicles.


  1. ^ Victora, Gabriel D.; Nussenzweig, Michel C. (2012-01-01). "Germinal centers". Annual Review of Immunology. 30: 429–457. doi:10.1146/annurev-immunol-020711-075032. ISSN 1545-3278. PMID 22224772.