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A centrocyte generally refers to a B cell with a cleaved nucleus,[1] as may appear in e.g. follicular lymphoma.[2]

During B cell development, centrocytes are formed following the cessation of centroblast proliferation. Centrocytes test their newly mutated antigen-binding sites (CDR loops) by re-expressing antigen on their surface.

Centrocyte can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen in lesions of lichen planus,[1] or a nondividing, activated B cell that expresses membrane immunoglobulin.[1]


  1. ^ a b c [1] Stedman's Medical Dictionary. 2006
  2. ^ Table 12-8 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.