During B cell development, centrocytes are formed following the cessation of centroblast proliferation. Centrocytes test their newly mutated antigen-binding sites (CDR loops) by re-expressing antigen on their surface.
Centrocyte can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen in lesions of lichen planus, or a nondividing, activated B cell that expresses membrane immunoglobulin.
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