Centromere protein E

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CENPE
Protein CENPE PDB 1t5c.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CENPE, CENP-E, KIF10, PPP1R61, MCPH13, Centromere protein E
External IDs MGI: 1098230 HomoloGene: 20429 GeneCards: 1062
RNA expression pattern
PBB GE CENPE 205046 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286734
NM_001813

NM_173762

RefSeq (protein)

NP_001273663.1
NP_001804.2

NP_776123.3

Location (UCSC) Chr 4: 103.11 – 103.2 Mb Chr 3: 135.21 – 135.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.[1][2]

Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.[2]

References[edit]

  1. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898. 
  2. ^ a b "Entrez Gene: CENPE centromere protein E, 312kDa". 

Further reading[edit]