Centromere protein E

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Centromere protein E, 312kDa
Protein CENPE PDB 1t5c.png
PDB rendering based on 1t5c.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CENPE ; CENP-E; KIF10; MCPH13; PPP1R61
External IDs OMIM117143 MGI1098230 HomoloGene20429 ChEMBL: 5870 GeneCards: CENPE Gene
RNA expression pattern
PBB GE CENPE 205046 at tn.png
More reference expression data
Species Human Mouse
Entrez 1062 229841
Ensembl ENSG00000138778 ENSMUSG00000045328
UniProt Q02224 Q6RT24
RefSeq (mRNA) NM_001286734 NM_173762
RefSeq (protein) NP_001273663 NP_776123
Location (UCSC) Chr 4:
103.11 – 103.2 Mb
Chr 3:
135.21 – 135.27 Mb
PubMed search [1] [2]

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.[1][2]

Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.[2]


  1. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898. 
  2. ^ a b "Entrez Gene: CENPE centromere protein E, 312kDa". 

Further reading[edit]