Cetyl alcohol

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Cetyl alcohol[1]
Skeletal formula
Space-filling model
IUPAC name
Other names
Cetanol, Cetyl alcohol, Ethal, Ethol, Hexadecanol, Hexadecyl alcohol, Palmityl alcohol
3D model (JSmol)
ECHA InfoCard 100.048.301
EC Number
  • 253-149-0
Molar mass 242.447 g·mol−1
Appearance White crystals or flakes
Odor very faint, waxy
Density 0.811 g/cm3
Melting point 49.3 °C (120.7 °F; 322.4 K)
Boiling point 344 °C (651 °F; 617 K)
Solubility Very soluble in ether, benzene, and chloroform.
Soluble in acetone.
Slightly soluble in alcohol.
log P 7.25[2]
Acidity (pKa) 16.20
-183.5·10−6 cm3/mol
1.4283 (79 °C)
Viscosity 53 cP (75 °C)
NFPA 704 (fire diamond)
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilHealth code 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
Flash point 185 °C (365 °F; 458 K)
Lethal dose or concentration (LD, LC):
5000 mg/kg (rat, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references

Cetyl alcohol /ˈstəl/, also known as hexadecan-1-ol and palmityl alcohol, is a fatty alcohol with the formula CH3(CH2)15OH. At room temperature, cetyl alcohol takes the form of a waxy white solid or flakes. The name cetyl derives from the whale oil (Latin: cetus) from which it was first isolated.[3]


Cetyl alcohol was discovered in 1817 by the French chemist Michel Chevreul when he heated spermaceti, a waxy substance obtained from sperm whale oil, with caustic potash (potassium hydroxide). Flakes of cetyl alcohol were left behind on cooling.[4] Modern production is based around the reduction of palmitic acid, which is obtained from palm oil.


Cetyl alcohol is used in the cosmetic industry as an opacifier in shampoos, or as an emollient, emulsifier or thickening agent in the manufacture of skin creams and lotions.[5] It is also employed as a lubricant for nuts and bolts, and is the active ingredient in some "liquid pool covers" (forming a surface layer to reduce evaporation and retain heat). Moreover, it can also be used as a cosurfactant in Emulsion applications.[6]

Side effects[edit]

People who suffer from eczema can be sensitive to cetyl alcohol,[7][8] though this may be due to impurities rather than cetyl alcohol itself.[9] However, cetyl alcohol is sometimes included in medications used for the treatment of eczema.[10]

Related compounds[edit]


  1. ^ Merck Index, 11th Edition, 2020.
  2. ^ "Hexadecan-1-ol_msds".
  3. ^ Nordegren, Thomas (2002). The A-Z Encyclopedia of Alcohol and Drug Abuse. Universal Publishers. p. 165. ISBN 1-58112-404-X.
  4. ^ Booth, James Curtis (1862). The Encyclopedia of Chemistry, Practical and Theoretical. p. 429.
  5. ^ Smolinske, Susan C (1992). Handbook of Food, Drug, and Cosmetic Excipients. CRC Press. pp. 75–76. ISBN 0-8493-3585-X.
  6. ^ Golemanov, Konstantin; Tcholakova, Slavka; Denkov, Nikolai D.; Gurkov, Theodor (April 2006). "Selection of Surfactants for Stable Paraffin-in-Water Dispersions, undergoing Solid−Liquid Transition of the Dispersed Particles". Langmuir. 22 (8): 3560–3569. doi:10.1021/la053059y. ISSN 0743-7463. PMID 16584227.
  7. ^ Gaul, LE (1969). "Dermatitis from cetyl and stearyl alcohols". Archives of Dermatology. 99 (5): 593. doi:10.1001/archderm.1969.01610230085016. PMID 4238421.
  8. ^ Soga, F; Katoh, N; Kishimoto, S (2004). "Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream". Contact Dermatitis. 50 (1): 49–50. doi:10.1111/j.0105-1873.2004.00271j.x. PMID 15059111.
  9. ^ Komamura, H; Doi, T; Inui, S; Yoshikawa, K (1997). "A case of contact dermatitis due to impurities of cetyl alcohol". Contact Dermatitis. 36 (1): 44–6. doi:10.1111/j.1600-0536.1997.tb00921.x. PMID 9034687.
  10. ^ Kato N; Numata T; Kanzaki T (1987). "Contact dermatitis due to Japanese pharmacopeia cetyl alcohol". Skin Research. 29 (suppl 3): 258–262.