|Preferred IUPAC name
|Systematic IUPAC name
Phenyl styryl ketone
|3D model (Jmol)||Interactive image|
|Molar mass||208.26 g·mol−1|
|Melting point||55 to 57 °C (131 to 135 °F; 328 to 330 K)|
|Boiling point||345 to 348 °C (653 to 658 °F; 618 to 621 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. Benzylideneacetophenone is the parent member of the chalcone series. The alternative name given to chalcone are phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone, ɣ-oxo-α,ɣ-diphenyl-α-propylene and α-phenyl-β-benzoylethylene.
Chalcones and their derivatives demonstrate wide range of biological activities such as anti-diabetic, anti-neoplastic, anti-hypertensive, anti-retroviral, anti-inflammatory, anti-parasitic, anti-histaminic, anti-malarial, anti-oxidant, anti-fungal, anti-obesity, anti-platelet, anti-tubercular, immunosuppressant, anti-arrhythmic, hypnotic, anti-gout, anxiolytic, anti-spasmodic, anti-nociceptive, hypolipidemic, anti-filarial, anti-angiogenic, anti-protozoal, anti-bacterial, anti-steroidal, cardioprotective, etc.
Chalcones have two absorption maxima at 280 nm and 340 nm.
This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones can be used as an example of green chemistry in undergraduate education. In a study investigating green syntheses, chalcones were synthesized from the same starting materials in high-temperature water (200 to 350 °C).
Substituted chalcones were also synthesised by piperidine-mediated condensation to avoid side reactions such as multiple condensations, polymerizations, and rearrangements.
- Merck Index, 11th Edition, 2028.
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- Mahapatra, Debarshi Kar; Bharti, Sanjay Kumar; Asati, Vivek (2015-06-15). "Anti-cancer chalcones: Structural and molecular target perspectives". European Journal of Medicinal Chemistry. 98: 69–114. doi:10.1016/j.ejmech.2015.05.004.
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