Chambers, Arizona was named after Edward Chambers, Vice President of the Aitchison, Topeka, & Santa Fe Railroad system. Chambers was responsible for opening the town's first post office in 1907. A native of Illinois, Chambers was instrumental of the development of the Railroad across the western United States- and is recognized as one of the men "Who Made San Francisco". Following many years with the Santa Fe Railroad System, Chambers became Director of the Division of of Traffic under President Herbert Hoover.
While not named after him, Charles Chambers was responsible for setting up a small trading post in Chambers, Arizona. The name was changed to Halloysite for a period in honor of clay that was mined nearby, but changed back to Chambers on June 1, 1930.