Charles M. Lieber
Charles M. Lieber
|Born||1959 (age 58–59)|
|Alma mater||Franklin & Marshall College|
|Known for||Nanomaterials synthesis and assembly|
Nanoelectronics and nanophotonics
|Awards||Wolf Prize in Chemistry (2012)|
MRS Von Hippel Award (2016)
|Fields||Nanoscience and nanotechnology|
|Doctoral students||Hongjie Dai|
Charles M. Lieber (born 1959) is an American chemist and pioneer in the field of nanoscience and nanotechnology. In 2011, Lieber was recognized by Thomson Reuters as the leading chemist in the world for the decade 2000-2010 based on the impact of his scientific publications. Lieber has published over 400 papers in peer-reviewed scientific journals and has edited and contributed to many books on nanoscience. He is the principal inventor on over fifty issued US patents and applications, and founded the nanotechnology company Nanosys in 2001 and Vista Therapeutics in 2007. He is known for his contributions to the synthesis, assembly and characterization of nanoscale materials and nanodevices, the application of nanoelectronic devices in biology, and as a mentor to numerous leaders in nanoscience.
Education and Research Philosophy
Lieber “spent much of his childhood building – and breaking – stereos, cars and model airplanes.” He obtained a B.A. in Chemistry from Franklin & Marshall College, graduating with honors in 1981. He went on to earn his doctorate at Stanford University in Chemistry, carrying out research on surface chemistry in the lab of Nathan Lewis, followed by a two year postdoc at Caltech in the lab of Harry Gray on long-distance electron transfer in metalloproteins. A self-confessed competitive person, Lieber feels “pressure to get things done quickly and – ideally – first” and to break new ground: “What I like to do as a scientist is to work on things that have not already been shown to work”. Studying the effects of dimensionality and anisotropy on the properties of quasi-2D planar structures and quasi-1D structures in his early career at Columbia and Harvard led him to become interested in the question of how one could make a one-dimensional wire, and to the epiphany that if a technology were to emerge from nascent work on nanoscale materials “it would require interconnections – exceedingly small, wire-like structures to move information around, move electrons around, and connect devices together.” Lieber was an early proponent of using the fundamental physical advantages of the very small to meld the worlds of optics and electronics and create interfaces between nanoscale materials and biological structures, and “to develop entirely new technologies, technologies we cannot even predict today.”
Lieber joined the Columbia University Department of Chemistry in 1987, where he was Assistant Professor (1987-1990) and Associate Professor (1990-1991) before moving to Harvard as Full Professor (1992). He now holds a joint appointment at Harvard University in the Department of Chemistry and Chemical Biology and the Harvard Paulson School of Engineering and Applied Sciences, as the Joshua and Beth Friedman University Professor. In 2015 he became Chair of the Department of Chemistry and Chemical Biology.
Lieber’s contributions to the rational growth, characterization, and applications of a range of functional nanoscale materials and heterostructures have provided concepts central to the bottom-up paradigm of nanoscience. These include rational synthesis of functional nanowire building blocks, characterization of these materials, and demonstration of their application in areas ranging from electronics, computing, photonics, and energy science to biology and medicine.
Nanomaterials synthesis. In his early work Lieber articulated the motivation for pursuing designed growth of nanometer-diameter wires in which composition, size, structure and morphology could be controlled over a wide range, and outlined a general method for the first controlled synthesis of free-standing single-crystal semiconductor nanowires, providing the groundwork for predictable growth of nanowires of virtually any elements and compounds in the periodic table. He proposed and demonstrated a general concept for the growth of nanoscale axial heterostructures and the growth of nanowire superlattices with new photonic and electronic properties, the basis of intensive efforts today in nanowire photonics and electronics. In parallel, he proposed and demonstrated the heterojunction concept of radial core-shell nanowire structures and single-crystalline multi-quantum well structures. Lieber also demonstrated a synthetic methodology to introduce controlled stereocenters – kinks – into nanowires, introducing the possibility of increasingly complex and functional nanostructures for three-dimensional nanodevices.
Nanostructure characterization. Lieber developed applications of scanning probe microscopies that could provide direct experimental measurement of the electrical and mechanical properties of individual carbon nanotubes and nanowires. This work showed that semiconductor nanowires with controlled electrical properties can be synthesized, providing electronically tunable functional nanoscale building blocks for device assembly. Additionally, Lieber invented chemical force microscopy to characterize the chemical properties of materials surfaces with nanometer resolution.
Nanoelectronics and nanophotonics. Lieber has used quantum-confined core/shell nanowire heterostructures to demonstrate ballistic transport, the superconducting proximity effect, and quantum transport. Other examples of functional nanoscale electronic and optoelectronic devices include nanoscale electrically driven lasers using single nanowires as active nanoscale cavities, carbon nanotube nanotweezers, nanotube-based ultrahigh-density electromechanical memory, an all-inorganic fully integrated nanoscale photovoltaic cell and functional logic devices and simple computational circuits using assembled semiconductor nanowires. These concepts led to the integration of nanowires on the Intel roadmap, and their current top-down implementation of these structures.
Nanostructure assembly and computing. Lieber has originated a number of approaches for parallel and scalable of assembly of nanowire and nanotube building blocks. The development of fluidic-directed assembly and subsequent large-scale assembly of electrically addressable parallel and crossed nanowire arrays was cited as one of the Breakthroughs of 2001 by Science. He also developed a lithography-free approach to bridging the macro-to-nano scale gap using modulation-doped semiconductor nanowires. Lieber recently introduced the assembly concept ‘nanocombing,’ which can be used to align nanoscale wires in a deterministic manner independent of material. He used this concept to create a programmable nanowire logic tile and the first stand-alone nanocomputer.
Nanoelectronics for biology and medicine. Lieber demonstrated the first direct electrical detection of proteins, selective electrical sensing of individual viruses and multiplexed detection of cancer marker proteins and tumor enzyme activity. His approach uses electrical signals for high-sensitivity, label-free detection, for use in wireless/remote medical applications. More recently, Lieber demonstrated a general approach to overcome the Debye screening that makes these measurements challenging in physiological conditions, overcoming the limitations of sensing with silicon nanowire field-effect devices and opening the way to their use in diagnostic healthcare applications. Lieber has also developed nanoelectronic devices for cell/tissue electrophysiology, showing that electrical activity and action potential propagation can be recorded from cultured cardiac cells with high resolution. Most recently, Lieber realized 3D nanoscale transistors in which the active transistor is separated from the connections to the outside world. His nanotechnology-enabled 3D cellular probes have shown point-like resolution in detection of single-molecules, intracellular function and even photons.
Nanoelectronics and brain science. The development of nanoelectronics-enabled cellular tools underpins Lieber’s views on transforming electrical recording and modulation of neuronal activity in brain science. Examples of this work include the integration of arrays of nanowire transistors with neurons at the scale that the brain is wired biologically, mapping functional activity in acute brain slices with high spatiotemporal resolution and a 3D structure capable of interfacing with complex neural networks. He developed macroporous 3D sensor arrays and synthetic tissue scaffold to mimic the structure of natural tissue, and for the first time generated synthetic tissues that can be innervated in 3D, showing that it is possible to produce interpenetrating 3D electronic-neural networks following cell culture. Lieber’s current work focuses on integrating electronics in a minimally/non-invasive manner within the central nervous system. Most recently, he has demonstrated that this macroporous electronics can be injected by syringe to position devices in a chosen region of the brain. Chronic histology and multiplexed recording studies demonstrate minimal immune response and noninvasive integration of the injectable electronics with neuronal circuitry. Reduced scarring may explain the mesh electronics’ demonstrated recording stability on time scales of up to a year. This concept of electronics integration with the brain as a nanotechnological tool potentially capable of treating neurological and neurodegenerative diseases, stroke and traumatic injury has drawn attention from a number of media sources. Scientific American named injectable electronics one of 2015’s top ten world changing ideas. Chemical & Engineering News called it “the most notable chemistry research advance of 2015.”
- ACS Award in the Chemistry of Materials 2004
- Inorganic Nanoscience Award, ACS Division of Inorganic Chemistry 2009
- Fred Kavli Distinguished Lectureship in Nanoscience, Materials Research Society 2010
- Wolf Prize in Chemistry 2012
- Nano Research Award, Tsinghua University Press/Springer 2013
- IEEE Nanotechnology Pioneer Award 2013
- Willard Gibbs Medal Award (2013)
- MRS Von Hippel Award 2016 (2016)
- Remsen Award 2016 
- NIH Director's Pioneer Award 2017
Other Honors and Positions
Lieber is an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine, the National Academy of Inventors, and an elected Foreign Member of the Chinese Academy of Sciences (2015). He is an elected Fellow of the Materials Research Society, American Chemical Society (Inaugural Class), Institute of Physics, International Union of Pure and Applied Chemistry (IUPAC), American Association for the Advancement of Science, and World Technology Network, and Honorary Fellow of the Chinese Chemical Society. In addition he belongs to the American Physical Society, Institute of Electrical and Electronics Engineers, International Society for Optical Engineering, Optical Society of America, Biophysical Society and Society for Neuroscience. Lieber is Co-editor of the journal Nano Letters, and serves on the editorial and advisory boards of a number of science and technology journals.
Since 2007 Lieber has grown giant pumpkins in his back yard in Lexington, MA. In 2010 he won the annual weigh-off at Frerich’s Farm in Rhode Island with a 1,610-lb pumpkin, and returned in 2012 with a 1,770-lb pumpkin that won 2nd place in that year’s weigh-off but set a Massachusetts record. His 1,870-lb pumpkin in 2014 was named the largest pumpkin in Massachusetts and ranked 17th largest in the world that year. The discrepancy between the size scales of his day job and hobby has been noted: “…on the one hand, Lieber’s chemistry “has had a defining influence on the field of nanoscience and nanotechnology,” according to his CV. On the other, his pumpkin could probably fill an entire Trader Joe’s with pumpkin specialty products for the fall season.”
- Molecular electronics
- Carbon nanotube
- Electrophysiological recording
- Top 100 Chemists, 2000-2010: Special Report on High-Impact Chemists, ScienceWatch, 10 February 2011.
- "Lieber Research Group - Publications".
- "Lieber Research Group - People - Charles M. Lieber".
- "Lieber Research Group - Former Group Members".
- "The incredible shrinking circuit". Scientific American. 285: 50–6. 2001.
- "An inside line on nanowires". ScienceWatch. 14: 1–5. 2003.
- "If nanoelectronics and living cells converge…". Pictures of the Future. Siemens. Spring 2010.
- "Forget what you know about nanotech". Business 2.0. November 2003.
- "A giant step toward miniaturization". Harvard Gazette. 22 July 2004.
- Zhang, Anqi; et al. (2016). Nanowires: Building blocks for nanoscience and nanotechnology. Springer.
- Lieber, Charles (2002). "Nanowires take the prize". Materials Today. 5 (2): 48. doi:10.1016/S1369-7021(02)05254-9.
- "One-dimensional nanostructures: Rational synthesis, novel properties and applications". Proceedings of the Robert A. Welch Foundation 40th Conference on Chemical Research: Chemistry on the Nanometer Scale. 165–187. 1997.
- Morales, A. M; Lieber, C. M (1998). "A laser ablation method for the synthesis of crystalline semiconductor nanowires". Science. 279 (5348): 208–11. Bibcode:1998Sci...279..208M. doi:10.1126/science.279.5348.208. PMID 9422689.
- "Controlled growth and electrical properties of heterojunctions of carbon nanotubes and silicon nanowires". Nature. 399: 48–51. 1999.
- "Growth of nanowire superlattice structures for nanoscale photonics and electronics". Nature. 617–20. 2002.
- "Scientists shell out on nanowires". Nanotechweb.org, 8 November 2002.
- Gevaux, David (2008). "Quantum wells meet nanowires". Nature Photonics. 2 (10): 594. doi:10.1038/nphoton.2008.190.
- Merali, Zeeya (2010). "Nano-hairpin peeks into cells". Nature. doi:10.1038/news.2010.402.
- Wong, Eric W; Sheehan, Paul E; Lieber, Charles M (1997). "Nanobeam Mechanics: Elasticity, Strength, and Toughness of Nanorods and Nanotubes". Science. 277 (5334): 1971–1975. doi:10.1126/science.277.5334.1971.
- Ouyang, M; Huang, J. L; Cheung, C. L; Lieber, C. M (2001). "Energy gaps in "metallic" single-walled carbon nanotubes". Science. 292 (5517): 702–5. Bibcode:2001Sci...292..702O. doi:10.1126/science.1058853. PMID 11326093.
- Frisbie, C. D; Rozsnyai, L. F; Noy, A; Wrighton, M. S; Lieber, C. M (1994). "Functional group imaging by chemical force microscopy". Science. 265 (5181): 2071–4. Bibcode:1994Sci...265.2071F. doi:10.1126/science.265.5181.2071. PMID 17811409.
- "Nanowire transistors outperform silicon switches". NewScientist.com, 24 May 2006.
- Belzig, Wolfgang (2006). "Super-semiconducting nanowires". Nature Nanotechnology. 1 (3): 167–168. Bibcode:2006NatNa...1..167B. doi:10.1038/nnano.2006.161. PMID 18654178.
- Eriksson, Mark A; Friesen, Mark (2007). "Nanowires charge towards integration". Nature Nanotechnology. 2 (10): 595–596. Bibcode:2007NatNa...2..595E. doi:10.1038/nnano.2007.314. PMID 18654378.
- Ball, Phillip (16 January 2003). "Lasers slim enough for chips". Nature News. doi:10.1038/news030113-5.
- Kim, P; Lieber, C. M (1999). "Nanotube nanotweezers". Science. 286 (5447): 2148–50. doi:10.1126/science.286.5447.2148. PMID 10591644.
- Rueckes, T; Kim, K; Joselevich, E; Tseng, G. Y; Cheung, C. L; Lieber, C. M (2000). "Carbon nanotube-based nonvolatile random access memory for molecular computing". Science. 289 (5476): 94–7. Bibcode:2000Sci...289...94R. doi:10.1126/science.289.5476.94. PMID 10884232.
- "Nanowire silicon solar cell for powering small circuits". IEEE Spectrum, 18 October 2007.
- Huang, Y; Duan, X; Cui, Y; Lauhon, L. J; Kim, K. H; Lieber, C. M (2001). "Logic gates and computation from assembled nanowire building blocks". Science. 294 (5545): 1313–7. Bibcode:2001Sci...294.1313H. doi:10.1126/science.1066192. PMID 11701922.
- "Will 5nm happen?". Semiconductor Engineering, 20 January 2016.
- Huang, Y; Duan, X; Wei, Q; Lieber, C. M (2001). "Directed assembly of one-dimensional nanostructures into functional networks". Science. 291 (5504): 630–3. Bibcode:2001Sci...291..630H. doi:10.1126/science.291.5504.630. PMID 11158671.
- "Breakthrough of 2001: Nanoelectronics". Science, 20 December 2001.
- Yang, C; Zhong, Z; Lieber, C. M (2005). "Encoding electronic properties by synthesis of axial modulation-doped silicon nanowires". Science. 310 (5752): 1304–7. Bibcode:2005Sci...310.1304Y. doi:10.1126/science.1118798. PMID 16311329.
- "Making the world's smallest gadgets even smaller". Harvard Gazette, 9 December 2005.
- Weiss, Nathan O; Duan, Xiangfeng (2013). "Untangling nanowire assembly". Nature Nanotechnology. 8 (5): 312–313. Bibcode:2013NatNa...8..312W. doi:10.1038/nnano.2013.83. PMID 23648735.
- "Scaled-down success: Programmable logic tiles could form basis of nanoprocessors". Scientific American, 9 February 2011.
- "Nanowire nanocomputer in new complexity record". Nanotechweb.org, 6 February 2014.
- Cui, Y; Wei, Q; Park, H; Lieber, C. M (2001). "Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species". Science. 293 (5533): 1289–92. Bibcode:2001Sci...293.1289C. doi:10.1126/science.1062711. PMID 11509722.
- "Nanodevices target viruses". Physicsworld.com, 8 October 2004.
- Eisenstein, Michael (2005). "Protein detection goes down to the wire". Nature Methods. 2 (11): 804–805. doi:10.1038/nmeth1105-804b.
- Gao, N; Zhou, W; Jiang, X; Hong, G; Fu, T. M; Lieber, C. M (2015). "General strategy for biodetection in high ionic strength solutions using transistor-based nanoelectronic sensors". Nano Letters. 15 (3): 2143–8. Bibcode:2015NanoL..15.2143G. doi:10.1021/acs.nanolett.5b00133. PMC 4594804. PMID 25664395.
- "Nanowire network measures cells' electrical signals". New Scientist, 22 April 2009.
- Pastrana, Erika (2010). "Reading cells from within". Nature Methods. 7 (10): 780–781. doi:10.1038/nmeth1010-780a.
- "Nanobiotechnology: Tiny cell transistor". Nature. 466 (7309): 904. 2010. Bibcode:2010Natur.466Q.904.. doi:10.1038/466904a.
- Lockwood, Tobias (2012). "Nano Focus: Nanoscale transistor measures living cell voltages". Mrs Bulletin. 37 (3): 184–186. doi:10.1557/mrs.2012.68.
- Kruskal, P. B; Jiang, Z; Gao, T; Lieber, C. M (2015). "Beyond the patch clamp: Nanotechnologies for intracellular recording". Neuron. 86 (1): 21–4. doi:10.1016/j.neuron.2015.01.004. PMID 25856481.
- "Harvard scientists use nanowires to connect neurons". Solid State Technology, 25 August 2006.
- Xie, C; Cui, Y (2010). "Nanowire platform for mapping neural circuits". Proceedings of the National Academy of Sciences of the United States of America. 107 (10): 4489–90. Bibcode:2010PNAS..107.4489X. doi:10.1073/pnas.1000450107. PMC 2842070. PMID 20194753.
- Qing, Q; Jiang, Z; Xu, L; Gao, R; Mai, L; Lieber, C. M (2014). "Free-standing kinked nanowire transistor probes for targeted intracellular recording in three dimensions". Nature Nanotechnology. 9 (2): 142–7. Bibcode:2014NatNa...9..142Q. doi:10.1038/nnano.2013.273. PMC 3946362. PMID 24336402.
- "Integrating man and machine". Chemical & Engineering News. 90 (52): 22. 24 December 2012.
- "A method for single-neuron chronic recording from the retina in awake mice". Science. 360: 1447–1451. 2018.
- "Syringe-injectable mesh electronics for stable chronic rodent electrophysiology". J. Vis. Exp. 137: e58003. 2018.
- Liu, J; Fu, T. M; Cheng, Z; Hong, G; Zhou, T; Jin, L; Duvvuri, M; Jiang, Z; Kruskal, P; Xie, C; Suo, Z; Fang, Y; Lieber, C. M (2015). "Syringe-injectable electronics". Nature Nanotechnology. 10 (7): 629–636. Bibcode:2015NatNa..10..629L. doi:10.1038/nnano.2015.115. PMC 4591029. PMID 26053995.
- Xie, C; Liu, J; Fu, T. M; Dai, X; Zhou, W; Lieber, C. M (2015). "Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes". Nature Materials. 14 (12): 1286–92. Bibcode:2015NatMa..14.1286X. doi:10.1038/nmat4427. PMID 26436341.
- Jarchum, Irene (2015). "A flexible mesh to record the brain". Nature Biotechnology. 33 (8): 830. doi:10.1038/nbt.3316. PMID 26252143.
- Fu, T. M; Hong, G; Zhou, T; Schuhmann, T. G; Viveros, R. D; Lieber, C. M (2016). "Stable long-term chronic brain mapping at the single-neuron level". Nature Methods. 13 (10): 875–82. doi:10.1038/nmeth.3969. PMID 27571550.
- "Injectable nanowires monitor mouse brains for months". IEEE Spectrum, 29 August 2016.
- "World changing ideas 2015". Scientific American Special Report, 17 November 2015.
- "Top research of 2015: Flexible electronics you can inject". Chemical & Engineering News Top Research of 2015.
- "Inorganic Nanoscience Award to Charles Lieber". Chemical and Engineering News. 87 (16): 58. 20 April 2009.
- "2012 Wolf Prize in Chemistry". ChemistryViews. 13 May 2012.
- "Springer and Tsinghua University Press award Nano Research Award". Springer.com. 20 October 2014.
- Morris, James (September 2013). "IEEE Nanotechnology Council Announces 2013 Winners". IEEE Nanotechnology Magazine: 30–31.
- "Charles M. Lieber Awarded the Materials Research Society's Highest Honor". Biospace.com. 9 December 2016.
- Wang, Linda (15 February 2016). "Remsen Award to Charles Lieber". Chemical & Engineering News. 94 (7): 33 – via American Chemical Society.
- "12 famous scientists elected 2015 CAS Foreign Members". Academic Divisions of the Chinese Academy of Sciences (CASAD), November 2015.
- "Chemistry professor Charles Lieber granted the honorary title of Fellow of the Chinese Chemical Society [in Chinese]". Chinese Chemical Society, October 25, 2009. Retrieved 2016-09-15.
- Mahoney, Bryan (11 October 2007). "Journey of the great pumpkins". YouTube.
- "Frerich's Farm Newsletter/November 2010".
- "Chem professor grows Mass.'s largest pumpkin, no plans for pie". The Harvard Crimson. 15 October 2014.
- "Nanoscientist grows giant pumpkin, crabs in costume". Chemical and Engineering News 92(43):40. 2014.
- "Harvard chemist grows insanely large pumpkin". Boston Magazine. 14 October 2014.