Charles Yanofsky

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Charles Yanofsky
Born (1925-04-17)April 17, 1925
New York City, New York, U.S.
Died 16 March 2018(2018-03-16) (aged 92)
Nationality United States
Alma mater City College of New York
Yale University (Ph.D, 1951)
Awards
Scientific career
Fields Genetics
Institutions Stanford University
Website profiles.stanford.edu/charles-yanofsky

Charles Yanofsky (April 17, 1925[1], New York City – March 16, 2018, Palo Alto, California) was an American geneticist.

Education and early life[edit]

Born in New York, Yanofsky studied at the City College of New York and at Yale University.[citation needed]

Career and research[edit]

In 1964, Yanofsky and colleagues established that gene sequences and protein sequences are colinear in bacteria.[2] Yanofsky showed that changes in DNA sequence can produce changes in protein sequence at corresponding positions.[3] His work revealed how controlled alterations in RNA structure allow RNA to serve as a regulatory molecule in both bacterial and animal cells.

Yanofsky was awarded the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1972[4] and was co-recipient of the Louisa Gross Horwitz Prize from Columbia University in 1976 with Seymour Benzer. Yanofsky was elected a foreign member of the Royal Society in 1985 and was one of the recipients of the 2003 National Medal of Science awards.

Charles Yanofsky was the Morris Herzstein Professor of Biology and Molecular Biology (Emeritus) in the Department of Biology at Stanford University.

Publications[edit]

  • Yanofsky, Charles (2007), "RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria", RNA (published Aug 2007), 13 (8), pp. 1141–54, doi:10.1261/rna.620507, PMC 1924887Freely accessible, PMID 17601995 
  • Yanofsky, Charles (2005), "The Favorable Features of Tryptophan Synthase for Proving Beadle and Tatum's One Gene–One Enzyme Hypothesis", Genetics (published Feb 2005), 169 (2), pp. 511–6, PMC 1449131Freely accessible, PMID 15731515 
  • Yanofsky, Charles (2004), "The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis", Trends Genet. (published Aug 2004), 20 (8), pp. 367–74, doi:10.1016/j.tig.2004.06.007, PMID 15262409 
  • Yanofsky, C (2000), "Transcription Attenuation: Once Viewed as a Novel Regulatory Strategy", J. Bacteriol. (published Jan 2000), 182 (1), pp. 1–8, doi:10.1128/JB.182.1.1-8.2000, PMC 94232Freely accessible, PMID 10613855 
  • Yanofsky, C; Konan, K V; Sarsero, J P (1996), "Some novel transcription attenuation mechanisms used by bacteria", Biochimie, 78 (11–12), pp. 1017–24, doi:10.1016/S0300-9084(97)86725-9, PMID 9150880 
  • Yanofsky, C (1988), "Transcription attenuation", J. Biol. Chem. (published Jan 15, 1988), 263 (2), pp. 609–12, PMID 3275656 
  • Yanofsky, C; Platt, T; Crawford, I P; Nichols, B P; Christie, GE; Horowitz, H; Vancleemput, M; Wu, AM (1981), "The complete nucleotide sequence of the tryptophan operon of Escherichia coli", Nucleic Acids Res. (published Dec 21, 1981), 9 (24), pp. 6647–68, doi:10.1093/nar/9.24.6647, PMC 327632Freely accessible, PMID 7038627 
  • Yanofsky, C (1981), "Attenuation in the control of expression of bacterial operons", Nature (published Feb 26, 1981), 289 (5800), pp. 751–8, doi:10.1038/289751a0, PMID 7007895 
  • Yanofsky, C (1971), "Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved", JAMA (published Nov 15, 1971), 218 (7), pp. 1026–35, doi:10.1001/jama.218.7.1026, PMID 4940311 
  • Yanofsky, C (1967), "Gene structure and protein structure", Harvey Lect., 61, pp. 145–68, PMID 5338072 

References[edit]

  1. ^ [1]
  2. ^ Yanofsky, Charles; Carlton, B. C.; Guest, J. R.; Helinski, D. R.; Henning, U. (Dec 18, 1963). "ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE". Proc Natl Acad Sci U S A. 51 (2): 266–272. doi:10.1073/pnas.51.2.266. PMC 300060Freely accessible. PMID 14124325. 
  3. ^ Yanofsky, C.; Drapeau, G. R.; Guest, J. R.; Carlton, B. C. (1967). "THE COMPLETE AMINO ACID SEQUENCE OF THE TRYPTOPHAN SYNTHETASE a PROTEIN (alpha SUBUNIT) AND ITS COLINEAR RELATIONSHIP WITH THE GENETIC MAP OF THE a GENE". Proceedings of the National Academy of Sciences of the United States of America. 57 (2): 296–298. doi:10.1073/pnas.57.2.296. PMC 335504Freely accessible. PMID 16591468. 
  4. ^ "Selman A. Waksman Award in Microbiology". National Academy of Sciences. Archived from the original on 12 January 2011. Retrieved 15 February 2011.