April 17, 1925|
New York City, New York, U.S.
|Died||16 March 2018(aged 92)|
City College of New York|
Yale University (Ph.D, 1951)
Education and early life
Career and research
In 1964, Yanofsky and colleagues established that gene sequences and protein sequences are colinear in bacteria. Yanofsky showed that changes in DNA sequence can produce changes in protein sequence at corresponding positions. His work revealed how controlled alterations in RNA structure allow RNA to serve as a regulatory molecule in both bacterial and animal cells.
Yanofsky was awarded the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1972 and was co-recipient of the Louisa Gross Horwitz Prize from Columbia University in 1976 with Seymour Benzer. Yanofsky was elected a foreign member of the Royal Society in 1985 and was one of the recipients of the 2003 National Medal of Science awards.
Charles Yanofsky was the Morris Herzstein Professor of Biology and Molecular Biology (Emeritus) in the Department of Biology at Stanford University.
- Yanofsky, Charles (2007), "RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria", RNA (published Aug 2007), 13 (8), pp. 1141–54, doi:10.1261/rna.620507, PMC , PMID 17601995
- Yanofsky, Charles (2005), "The Favorable Features of Tryptophan Synthase for Proving Beadle and Tatum's One Gene–One Enzyme Hypothesis", Genetics (published Feb 2005), 169 (2), pp. 511–6, PMC , PMID 15731515
- Yanofsky, Charles (2004), "The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis", Trends Genet. (published Aug 2004), 20 (8), pp. 367–74, doi:10.1016/j.tig.2004.06.007, PMID 15262409
- Yanofsky, C (2000), "Transcription Attenuation: Once Viewed as a Novel Regulatory Strategy", J. Bacteriol. (published Jan 2000), 182 (1), pp. 1–8, doi:10.1128/JB.182.1.1-8.2000, PMC , PMID 10613855
- Yanofsky, C; Konan, K V; Sarsero, J P (1996), "Some novel transcription attenuation mechanisms used by bacteria", Biochimie, 78 (11–12), pp. 1017–24, doi:10.1016/S0300-9084(97)86725-9, PMID 9150880
- Yanofsky, C (1988), "Transcription attenuation", J. Biol. Chem. (published Jan 15, 1988), 263 (2), pp. 609–12, PMID 3275656
- Yanofsky, C; Platt, T; Crawford, I P; Nichols, B P; Christie, GE; Horowitz, H; Vancleemput, M; Wu, AM (1981), "The complete nucleotide sequence of the tryptophan operon of Escherichia coli", Nucleic Acids Res. (published Dec 21, 1981), 9 (24), pp. 6647–68, doi:10.1093/nar/9.24.6647, PMC , PMID 7038627
- Yanofsky, C (1981), "Attenuation in the control of expression of bacterial operons", Nature (published Feb 26, 1981), 289 (5800), pp. 751–8, doi:10.1038/289751a0, PMID 7007895
- Yanofsky, C (1971), "Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved", JAMA (published Nov 15, 1971), 218 (7), pp. 1026–35, doi:10.1001/jama.218.7.1026, PMID 4940311
- Yanofsky, C (1967), "Gene structure and protein structure", Harvey Lect., 61, pp. 145–68, PMID 5338072
- Yanofsky, Charles; Carlton, B. C.; Guest, J. R.; Helinski, D. R.; Henning, U. (Dec 18, 1963). "ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE". Proc Natl Acad Sci U S A. 51 (2): 266–272. doi:10.1073/pnas.51.2.266. PMC . PMID 14124325.
- Yanofsky, C.; Drapeau, G. R.; Guest, J. R.; Carlton, B. C. (1967). "THE COMPLETE AMINO ACID SEQUENCE OF THE TRYPTOPHAN SYNTHETASE a PROTEIN (alpha SUBUNIT) AND ITS COLINEAR RELATIONSHIP WITH THE GENETIC MAP OF THE a GENE". Proceedings of the National Academy of Sciences of the United States of America. 57 (2): 296–298. doi:10.1073/pnas.57.2.296. PMC . PMID 16591468.
- "Selman A. Waksman Award in Microbiology". National Academy of Sciences. Archived from the original on 12 January 2011. Retrieved 15 February 2011.
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