Charlie Wilson's War may refer to:
- The efforts of U.S. Representative Charlie Wilson (D-TX) to help the Afghan Mujahideen fight Soviet forces through...
- ...the CIA's Operation Cyclone, the official name of the covert war itself
- Charlie Wilson's War: The Extraordinary Story of the Largest Covert Operation in History, a 2003 book by George Crile III documenting the above events
- Charlie Wilson's War (film), a 2007 film directed by Mike Nichols based on the book