Saul Milton (Chase) and Will Kennard (Status) originally met in London through a mutual friend although met up again whilst university students in Manchester. Will studied History of Art at the University of Manchester, while Saul studied English and Humanities at Manchester Metropolitan University. Will decided to drop out of university to pursue a music career although Saul did manage to achieve an honours in his studies despite spending most of his time on music.
Chase & Status had three number one singles on the UK Dance Chart between 2007 - 2009; the double A-side "Hurt You" / "Sell Me Your Soul" in 2007 and "Take Me Away" / "Judgement (Informer)" in 2008 were two of them. On 5 October 2008, they reached number seventy on the UK Singles Chart and number one on the UK Dance Chart again with their single "Pieces" featuring vocals from Plan B. In 2009, they peaked at number forty five with "Against All Odds", which featured UK rapper Kano.
In November 2009, the duo entered the top forty of the UK Singles Chart for the first time with the track "End Credits". The track was released on 2 November 2009 and featuring Plan B, it reached a peak of number nine on the UK Singles Chart.
The duo then released "Let You Go" on 15 August 2010, revealing it to be the second official single to be released from their second studio album No More Idols, according to posters outside their album launch show at HMV Forum in Kentish Town on 21 October. The single featured vocals from Mali and debuted at number eleven on the UK Singles Chart, marking the duo's second consecutive Top Forty hit. "Hypest Hype" (featuring Tempa T) was confirmed in October 2010 to be the third single from the album. Because it was released as a free download from their website on 8 November 2010, it did not qualify to chart. The fourth single from the album is "Blind Faith", which features soul singer/songwriter Liam Bailey and was released in January 2011. Other singles include "Time" (featuring Delilah), "Hitz" (featuring Tinie Tempah) and "Flashing Lights" (with Sub Focus featuring Takura). The album also contains the song "Heavy" with Dizzee Rascal. The album debuted at number two on the UK Albums Chart and was certified Gold in the first week of sales by the British Phonographic Industry.
In contrast to More Than Alot and No More Idols, the new album has a darker sound. The duo performed as a sub-headline on Friday night at Download Festival 2012, provoking an outcry from regular Download enthusiasts (the festival is recognized as a rock/metal festival), not least due to them being higher on the bill than fan favourites Machine Head, who had been subject to an internet campaign to headline the festival. However, they were well received. Chase & Status have also headlined electronic music festival South West Four hosted on London's Clapham Common. Chase & Status: Live at Brixton, a CD/DVD featuring appearances from Tinie Tempah, Liam Bailey, Mali & Delilah, was released on 2 April 2012. On 15 October 2012, the track "Big Man" featuring Liam Bailey was released on the official Chase & Status website as a free download. The following day it was released through online retailers. The music video was also published on 15 October on their official YouTube channel and the 'UKFDrumandBass' channel.
On 8 March 2013, the duo were confirmed to headline Saturday night at Roskilde Festival following Metallica at Orange stage. On 11 March 2013, the duo were confirmed through their website to sub-headline Saturday night at Reading Festival and Sunday night at Leeds Festival 2013. On 4 June 2013, the album's lead single "Lost & Not Found" featuring Louis M^ttrs was uploaded to the 'ChaseAndStatusVEVO' channel. The digital single was released on 26 June and includes remixes from MTA Records artists Dream Mclean, Kove and Josh Butler. On 17 June 2013, MTA Records announced that newly signed Elli Ingram will support them on tour and feature on the album. On 26 July 2013, they announced the album title to be Brand New Machine. The album's second single "Count on Me" featuring Moko premiered on B.Traits' BBC Radio 1 show on the same day, and the official album artwork was released. "Count On Me" was released on 29 September. The album was released on 7 October. On 24 August 2013, they performed on the Main Stage at Reading Festival before Eminem. During the performance, MC Rage had to stop the show due to people being crushed at the front of the crowd. The act was resumed, and finished successfully. They headlined 1Xtra Live in Bournemouth on 7 October, the same day as the album release, and returned to the BIC on their arena tour in November. The band played their first show in India during the popular multi-genre music festival, Bacardi NH7 Weekender on 20 October 2013.
On 25 July 2014, they headlined Friday night on the mainstage at Global Gathering festival. Despite the performance being a roaring success, attracting the second largest crowd after Saturday headliners The Prodigy, the festival's memory was tainted with the death of a man on the Friday night. For 2014's Red Bull Culture Clash, Chase & Status joined forces with Shy FX, David Rodigan and MC Rage to form the soundsystem Rebel Sound. They went on to win the clash, defeating fellow crews Stone Love, Boy Better Know and A$AP Mob. On 21 and 28 November 2014, they headlined the UK's largest indoor winter music festival, The Big Reunion. On 30 December, they played last on the main stage of Rhythm & Vines, New Zealand's biggest festival, in front of 30,000 people, delivering a powerful 2h30 non stop set.