Chauncey Depew Leake (September 5, 1896 – January 11, 1978) was an American pharmacologist, medical historian and ethicist. Leake received a bachelor’s degree with majors in biology, chemistry, and philosophy from Princeton University. He received his M.S. (1920) and Ph.D. (1923) from the University of Wisconsin in pharmacology and physiology.
At age 10, Leake was treated by the ophthalmologist Karl Koller.
Leake discovered the anaesthetic divinyl ether. One of his publications was a translation of the 1628 physiological work De motu cordis (On the Motion of the Heart) from Latin to English.