Chemical modification

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Chemical modification refers to a number of various processes involving the alteration of the chemical constitution or structure of molecules.

Chemical modification in chemistry[edit]

Chemical modification describes the modification, addition or removal, through chemical reaction, of any of a variety of macromolecules, including proteins and nucleic acids.

Chemically modified electrodes[edit]

Chemically modified electrodes are electrodes that have their surfaces chemically modified to change the electrode's physical, chemical, electrochemical, optical, electrical, and transport properties. These electrodes are used for advanced purposes in research and investigation.[1]

Chemical modification in biochemistry[edit]

In biochemistry, chemical modification is the technique of chemically reacting a protein or nucleic acid with chemical reagents. Chemical modification can have several goals, such as

  • to identify which parts of the molecule are exposed to solvent ("foot printing");
  • to determine which residues are important for a particular phenotype, e.g., which residues are important for an enzymatic activity;
  • to introduce new groups into a macromolecule; and
  • to crosslink macromolecules intra- and intermolecularly.

Chemical modification of protein side chains[edit]

Chemical modification of nucleic acids[edit]


  1. ^ Durst, R., Baumner, A., Murray, R., Buck, R., & Andrieux, C., "Chemically modified electrodes: Recommended terminology and definitions (PDF)", IUPAC, 1997, pp 1317–1323.