Chen Mingshu (simplified Chinese: 陈铭枢; traditional Chinese: 陳銘枢; October 15, 1889 – May 15, 1965) was a Chinese general and politician. A Hakka from Hepu, Guangxi, he graduated from Baoding Military Academy and participated in the Northern Expedition. He was briefly premier after Chiang Kai-shek stepped down in December 1931. He took part in the Battle of Shanghai (1932), defending the city against the Japanese Empire.
He was one of the principal leaders of the Fujian Rebellion and the Productive People's Party, the failure of which forced him into exile in Hong Kong. In 1948, he joined the Revolutionary Committee of the Kuomintang's central standing committee. After the People's Republic of China was founded, he sat on the standing committees of the Chinese People's Political Consultative Conference and the National People's Congress. During the Anti-Rightist Movement, he was determined to be a "rightist", and was forced out of politics.