Cherenkov luminescence imaging

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Cherenkov luminescence imaging (CLI) is an emerging imaging modality, similar to bioluminescence imaging, that captures visible photons emitted by Cherenkov radiation. It basically is the optical imaging of radiotracers that emit charged particles traveling faster than the phase velocity of light in that particular medium. It can be used to quickly evaluate radio tracers in preclinical research[1][2] but also to obtain clinical images in patients.[3] While radioactivity itself can not be modified, the emitted light provides an opportunity to generate radioactivity-based activatable or "smart" imaging agents that sense for example enzymatic activity.[4]


  1. ^ Ruggiero, A; Holland, J. P.; Lewis, J. S.; Grimm, J (2010). "Cerenkov luminescence imaging of medical isotopes". Journal of Nuclear Medicine. 51 (7): 1123–1130. doi:10.2967/jnumed.110.076521. PMC 3068779Freely accessible. PMID 20554722. 
  2. ^ Zhong, J.; Qin, C.; Yang, X.; Zhu, S.; Zhang, X.; Tian, J (2011). "Cerenkov luminescence tomography for in vivo radiopharmaceutical imaging". International Journal of Biomedical Imaging. 2011 (641618): 1–6. doi:10.1155/2011/641618. 
  3. ^ Thorek, D. L.; Riedl, C. C.; Grimm, J (2013). "Clinical Cerenkov Luminescence Imaging of 18F-FDG". Journal of Nuclear Medicine. 55 (1): 95–98. doi:10.2967/jnumed.113.127266. PMC 3903390Freely accessible. PMID 24078721. 
  4. ^ Thorek, Daniel L J; Ogirala, Anuja; Beattie, Bradley J; Grimm, Jan (2013). "Quantitative imaging of disease signatures through radioactive decay signal conversion". Nature Medicine. 19 (10): 1345–50. doi:10.1038/nm.3323. PMC 3795968Freely accessible. PMID 24013701.