Chimerin 2

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CHN2
Protein CHN2 PDB 1xa6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
External IDs MGI: 1917243 HomoloGene: 31213 GeneCards: CHN2
RNA expression pattern
PBB GE CHN2 213385 at fs.png

PBB GE CHN2 211419 s at fs.png

PBB GE CHN2 207486 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163640
NM_023543
NM_001311133
NM_001311134

RefSeq (protein)
Location (UCSC) Chr 7: 29.12 – 29.51 Mb Chr 6: 54.04 – 54.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.[3][4]

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leung T, How BE, Manser E, Lim L (Jun 1994). "Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain". J Biol Chem. 269 (17): 12888–92. PMID 8175705. 
  4. ^ a b "Entrez Gene: CHN2 chimerin (chimaerin) 2". 

Further reading[edit]