Chitin-glucan complex

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Chitin-glucan complex (CGC) is a copolymer (polysaccharide) that makes up fungal cell walls, consisting of covalently-bonded chitin and branched 1,3/1,6-ß-D-glucan. CGCs are alkaline-insoluble. Different species of fungi have different structural compositions of chitin and ß-glucan making up the CGCs in their cell walls.[1] Soil composition and other environmental factors can also affect the ratio of chitin to ß-glucan found in the CGC.[2] Fungal cell walls may also contain chitosan-glucan complexes, which are similar copolymers but have chitosan instead of chitin. Chitin and chitosan are closely related molecules: greater than 40% of the polymer chain of chitin is made of acetylated glucosamine units, whereas greater than 60% of chitosan is made of deacetylated glucosamine units.[1]

In their natural form, CGCs provide structural support to the fungal cell wall.[3] Biomedical applications of CGCs have been studied, including the immunostimulant properties of A. fumigatus, as well as successful antibacterial activity against S. typhimurium by CGCs from A. niger and M. rouxii.[1] There is some evidence that CGCs can act as an effective prebiotic, as it was tested on growing 100 different bifdobacterial strains as well as on rats in vivo.[4] CGCs have many industrial applications, such as in food, cosmetics, and textiles industries, because they can be prepared easily without toxins. As food additives, they are commonly used due to their ability to adsorb heavy metal ions.[5] Additionally, CGCs are produced in high volume industrially because they can be broken down into their constitutive components by hydrolysis, producing pure chitin (or chitosan) and ß-glucans.[3]

Rather than being produced from animal parts, pure chitin can be extracted from the cell walls of the fungus Pichia pastoris, recently classified as Komagataella pastoris. Unlike chitin extracted from crustaceans, for example, this chitin contains no heavy metals. A study revealed that the complex exhibits traces of α-chitin in the molecular structure via x-ray diffraction. The similarities in structure and physical properties suggest that the complex is a suitable alternative to crustacean-based chitin as fungi are a more feasible and reliable source of raw materials.[6]

The 1,3/1,6-ß-D-glucan in this complex are macromolecules consisting solely of the carbohydrate glucose. There are many varieties of glucan. The main difference lies in the effectiveness and efficiency of these glucans. According to the most recent experimental studies, it is one of the most effective activators. 1,3/1,6-ß-D-glucan complex boosts the immune system of humans and other animals.


  1. ^ a b c Freitas, Filomena; Roca, Christophe; Reis, Maria A.M. (2015). "Fungi as Sources of Polysaccharides for Pharmaceutical and Biomedical Applications". In Thakur, VK; Thakur, MK (eds.). HANDBOOK OF POLYMERS FOR PHARMACEUTICAL TECHNOLOGIES: VOL 3, BIODEGRADABLE POLYMERS. Scrivener Publishing. pp. 61–103. ISBN 978-1-119-04144-3.
  2. ^ Ivshin, V. P.; Artamonova, S. D.; Ivshina, T. N.; Sharnina, F. F. (Dec 2007). "Methods for isolation of chitin-glucan complexes from higher fungi native biomass". Polymer Science Series B. 49 (11–12): 305–310. doi:10.1134/s1560090407110097. ISSN 1560-0904.
  3. ^ a b Roca, Christophe; Chagas, Bárbara; Farinha, Inês; Freitas, Filomena; Mafra, Luís; Aguiar, Filipe; Oliveira, Rui; Reis, Maria A.M. (Nov 2012). "Production of yeast chitin–glucan complex from biodiesel industry byproduct". Process Biochemistry. 47 (11): 1670–1675. doi:10.1016/j.procbio.2012.04.004.
  4. ^ Alessandri, Giulia; Milani, Christian; Duranti, Sabrina; Mancabelli, Leonardo; Ranjanoro, Thibaut; Modica, Salvatore; Carnevali, Luca; Statello, Rosario; Bottacini, Francesca; Turroni, Francesca; Ossiprandi, Maria Cristina (2019-04-08). "Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota". Scientific Reports. 9 (1): 5755. Bibcode:2019NatSR...9.5755A. doi:10.1038/s41598-019-42257-z. ISSN 2045-2322. PMC 6453949. PMID 30962486.
  5. ^ Meichik, N.R.; Vorob’ev, D.V. (May 2012). "Chitin–Glucan Complex in Cell Walls of the Peltigera aphthosa Lichen". Applied Biochemistry and Microbiology. 48 (3): 307–311. doi:10.1134/S0003683812030088. PMID 22834307. S2CID 15173850.
  6. ^ Farinha, Inês; Duarte, Paulo; Pimentel, Ana; Plotnikova, Evgeniya; Chagas, Bárbara; Mafra, Luís; Grandfils, Christian; Freitas, Filomena; Fortunato, Elvira; Reis, Maria A.M. (2015). "Chitin–glucan complex production by Komagataella pastoris : Downstream optimization and product characterization". Carbohydrate Polymers. 130: 455–464. doi:10.1016/j.carbpol.2015.05.034. PMID 26076647.