3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||309.52 g·mol−1|
|Melting point||176 to 182 °C (349 to 360 °F; 449 to 455 K)|
|Main hazards||Harmful if swallowed|
Harmful if inhaled
|GHS Signal word||Danger|
|H301, H332, H336, H400, H410|
|P261, P264, P270, P271, P273, P301+310, P304+312, P304+340, P312, P321, P330, P391, P403+233, P405, P501|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Chloralose (also known as α-chloralose) is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.
It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)
Chloralose exerts barbiturate-like actions on synaptic transmission in the brain, including potent effects at inhibitory γ-aminobutyric acid type A (GABAA) receptors. A structural isomer of chloralose, β-chloralose (also called parachloralose in older literature), is inactive as a GABAA modulator and also as a general anesthetic.
- Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.
- R. A. Nicoll & J. M. Wojtowicz (1980). "The effects of pentobarbital and related compounds on frog motoneurons". Brain Research. 191 (1): 225–237. PMID 6247012.
- K. M. Garrett & J. Gan (1998). "Enhancement of gamma-aminobutyric acidA receptor activity by alpha-chloralose". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 680–686. PMID 9580613.
- M. D. Krasowski & N. L. Harrison (2000). "The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations". British Journal of Pharmacology. 129 (4): 731–743. doi:10.1038/sj.bjp.0703087. PMC 1571881. PMID 10683198.
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