Chloroethylnorapomorphine

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Chloroethylnorapomorphine
Chloroethylnorapomorphine.png
Names
IUPAC name
6-(2-Chloro-ethyl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Other names
(−)-N-(2-Chloroethyl)-norapomorphine
Identifiers
75946-94-0 N
ChEMBL ChEMBL283871 YesY
ChemSpider 137707 YesY
Jmol-3D images Image
PubChem 156376
Properties
C18H18ClNO2
Molar mass 315.80 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Chloroethylnorapomorphine is a chemical once thought to be an irreversible dopamine D2 receptor antagonist;[1][2] however, it was later proved to be reversible.[3]

References[edit]

  1. ^ Cohen, SA; Neumeyer, JL. (Oct 1983). "Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist". Journal of Medicinal Chemistry 26 (10): 1348–53. doi:10.1021/jm00364a003. PMID 6620296. 
  2. ^ Guan, JH; Neumeyer, JL; Filer, CN; Ahern, DG; Lilly, L; Watanabe, M; Grigoriadis, D; Seeman, P. (Jun 1984). "N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application". Journal of Medicinal Chemistry 27 (6): 806–10. doi:10.1021/jm00372a019. PMID 6737423. 
  3. ^ Lehmann, J; Langer, SZ (1982). "Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine". European Journal of Pharmacology 77 (1): 85–6. doi:10.1016/0014-2999(82)90542-8. PMID 7060630.