Chlorothiazide

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Chlorothiazide
Chlorothiazide.svg
Chlorothiazide-from-xtal-3D-balls.png
Clinical data
Trade names Diuril
AHFS/Drugs.com Monograph
MedlinePlus a682341
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability low
Metabolism Nil
Biological half-life 45 to 120 minutes
Excretion Renal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.368
Chemical and physical data
Formula C7H6ClN3O4S2
Molar mass 295.72 g/mol
3D model (JSmol)
  (verify)

Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.[1]

It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

It was discovered in 1957.[2]

Indications[edit]

Contraindications[edit]

Side effects[edit]

History[edit]

The Research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.[3]

References[edit]

  1. ^ Ernst, Michael E.; Grimm, Richard H., Jr. "Thiazide diuretics: 50 years and beyond" Current Hypertension Reviews 2008, volume 4(4), pp. 256-265. doi:10.2174/157340208786241264
  2. ^ Walker, S. R. (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 9789400926592. 
  3. ^ Foundation, Lasker. "Historical Awards - The Lasker Foundation". The Lasker Foundation.