Chlorphenesin

Chlorphenesin
Names
	IUPAC name 3-(4-Chlorophenoxy)propane-1,2-diol
	Other names Chlorphenesin
Identifiers
CAS Number	104-29-0;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:3642;
ChEMBL	ChEMBL388751;
ChemSpider	7411;
ECHA InfoCard	100.002.902
EC Number	203-192-6;
KEGG	C07928;
PubChem CID	7697;
UNII	I670DAL4SZ;
CompTox Dashboard (EPA)	DTXSID0049028 ;
	InChI InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2 Key: RLLPVAHKSCTKIL-UHFFFAOYSA-N;
	SMILES C1=CC(=CC=C1OCC(CO)O)Cl;
Properties
Chemical formula	C9H11ClO3
Molar mass	202.63 g·mol−1
Melting point	77 to 78 °C (171 to 172 °F; 350 to 351 K)
Solubility in water	10.4 g/L
log P	1.2
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H302, H315, H318, H319, H332, H335
Precautionary statements	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chlorphenesin is a synthetic chemical used as a preservative in certain cosmetics. Owing to its antifungal and antibacterial properties; it is classified as an antifungal for topical use by the WHO.^[2] The major adverse effect from this preservative on skin is allergic contact sensitivity.^[3]^[4] Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.^[5]

References

↑ PubChem. "Chlorphenesin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-07-15.
↑ ATC code D01AE07
↑ Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. S2CID 37580364.
↑ Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (4): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223. S2CID 43810471.
↑ "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants". Food and Drug Administration. Archived from the original on June 18, 2009.

[1] PubChem. "Chlorphenesin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-07-15.

[2] ATC code D01AE07

[3] Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. S2CID 37580364.

[4] Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (4): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223. S2CID 43810471.

[5] "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants". Food and Drug Administration. Archived from the original on June 18, 2009.

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