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X-ray of a knee with chondrocalcinosis.

Chondrocalcinosis is calcification in hyaline and/or fibrocartilage.[1] It can be seen on radiography.


A common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD).[2]

Hypomagnesemia may cause chondrocalcinosis, and magnesium supplementation may reduce or alleviate symptoms.[3] In some cases, arthritis from injury can cause chondrocalcinosis.[4]

Other causes of chondrocalcinosis include:[2]


Chondrocalcinosis can be visualized on projectional radiography, CT scan, MRI, US, and nuclear medicine.[1] CT scans and MRIs show calcific masses (usually within the ligamentum flavum or joint capsule), however radiography is more successful.[1] At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage.[5] As with most conditions, chondrocalcinosis can present with similarity to other diseases such as ankylosing spondylitis and gout.[1]


  1. ^ a b c d Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology)
  2. ^ a b Matt A. Morgan; Frank Gaillard; et al. "Chondrocalcinosis". Radiopedia. Retrieved 2017-08-11.
  3. ^ de Filippi JP, Diderich PP, Wouters JM (1992). "Hypomagnesemia and chondrocalcinosis". Ned Tijdschr Geneeskd. 136 (20): 139–41. PMID 1732847.
  4. ^ Wright GD, Doherty M (1997). "Calcium pyrophosphate crystal deposition is not always 'wear and tear' or aging". Ann. Rheum. Dis. 56 (10): 586–8. doi:10.1136/ard.56.10.586. PMC 1752269. PMID 9389218.
  5. ^ Arend CF. Ultrasound of the Shoulder. Master Medical Books, 2013. Free chapter on acromioclavicular chondrocalcinosis is available at