The New Yorker described him as "...A singer, guitarist, and songwriter who rose through the local club scene in the nineteen-eighties, Harford operates in the free zone outside rock's usual categories. He has a foot in country, a hand in seventies rock, a toe in folk, a finger in post-punk. With his gruff but plaintive voice and his fondness for muddied-up guitars, he sometimes recalls Neil Young...". And according to National Public Radio, his music "has been described as 'beautiful, heart-rending and soulful,' as well as 'dark, rocking and dangerous'".
Harford's backing band, The Band of Changes, is a revolving door concept which has included notable musicians such as Kevin Salem, Jane Scarpantoni, members of Ween including Dave Dreiwitz, Scott Metzger, Robert Seahag Mangano, Joe Russo, Eric Slick, Richard Thompson, and Michael Hampton.
In the early 1980s Harford was a member of the Boston based band Three Colors that included Hub Moore, whose major label debut on Slash/London Records Harford produced in 1996; and saxophonist Dana Colley, who went on to be a member of the band Morphine.
In 1992, as Chris Harford and the First Rays of the New Rising Sun, he released Be Headed on Elektra Records. Subsequently, he released several albums independently:" Comet; Band of Changes; Wake; Live at CBGB's; Sing, Breathe, & Be Merry; and Time Warp Deck. His sixth studio album, Looking Out For Number 6 (2006), was produced by Dean Ween (who also contributed drums and lead guitar) and released by Schnitzel Records Ltd..
- Official Chris Harford site
- Trouser Press reviews of some Chris Harford albums
-  Hub Moore
-  Hendrix Lacrosse
-  Michel Schlumberger Wines