Slade received his highest exposure in November 1989 when he was asked to join AC/DC after their then-drummer Simon Wright had departed. AC/DC were signed to the same management company as Gary Moore who Slade had just finished touring with. The Young brothers (Angus and Malcolm) initially hired Slade only temporarily through management, then asked him during the recording of the only album he made with them, to join the band. Slade played on The Razors Edge album in 1990 and the accompanying world tour, and the "Big Gun" single released in 1993. According to Slade, after working on demos for the following album, Ballbreaker, Malcolm Young called Slade and told him they wanted to try a reunion with former drummer Phil Rudd. Slade replied, "That's me out then, I'm gone." Young said that he wanted to keep Slade on hand if Rudd's return did not work out, but Slade refused. However, he had made statements that he still got on well with AC/DC and "it was an honour and a privilege to play with those guys".
After his departure, Slade spent a few years living in the UK countryside before receiving a call from Geoff Downes from the British progressive rock group Asia. Slade was with Asia for six years, before departing in September 2005.
Slade has fronted an AC/DC tribute band called Chris Slade Steel Circle, and toured with The Chris Slade Timeline – a band formed to celebrate 50 years as a rock drummer. The band takes music from all aspects of his lengthy career. In Slade’s absence, the band continues to tour under the name Centaur Parting.
Speculation regarding Slade's return to AC/DC started shortly after Phil Rudd’s legal troubles became public. In a December 2014 podcast by Chris Jericho, Jericho mentioned that he had it on good authority that Slade would be returning to AC/DC. Slade was photographed signing albums with the band on 7 February 2015. After the photo appeared publicly, Slade finally admitted that he was going to be the band’s drummer and admitted to secrecy surrounding his return, and stated that it was done for the right reasons. Since Slade's return, the band has issued a statement stating that, “Chris Slade will be on drums for the upcoming Rock or Bust world tour.” Since that time, in addition to playing live, Slade has appeared in all promotional photos taken with the band and appeared in the music video for the single, “Rock the Blues Away.” In late April 2015, AC/DC's official web site listed him as the band's drummer.