Settipani is best known for his work on the genealogy and prosopography of elites in Europe and the Near East. He has given particular attention to the possibility of genealogical continuity among the families of late antiquity and the early mediaeval period, as revealed by shared naming patterns among the families. Settipani is co-founder and general editor with Katharine S. B. Keats-Rohan of the publication series of the Unit for Prosopographical Research, Linacre College, Oxford University.
Settipani's work is one important example of the trend in Early Mediaeval Historical Studies away from the idea, dominant for centuries, that elites of the late Roman Empire were entirely displaced in the West by unrelated Germanic invaders and "new men" or alternatively that to the extent they may not have been displaced memories of their origins and ties have become irretrievably obscured. This has contributed to better understanding of familial relations, society and politics of that era through a broad presentation of the subject matter, extensive citation of prior research and alternative viewpoints together with solutions to genealogical and prosopographical questions and, in addition to his own publications, has been extensively cited in scholarly papers and books on Early Medieval Western European History, although a few have expressed concern that the very breadth and volume of the material he treats in a single work tend to make it more difficult to evaluate his conclusions and their implications for specific historical contexts and argue that his presentation lacks accessibility.
^Beech, 2004, p. 286 "In presenting the latest views about the family origins and affiliations of the great noble families of southern France in the Carolingian period, this book will be indispensable to any scholar seeking information about the individuals and families in question."
Ralph Mathisen, Ruricius of Limoges and Friends: A Collection of Letters from Visigothic Gaul. Liverpool University Press(1999)
Constance Brittain Bouchard, Those of My Blood: Constructing Noble Families in Medieval Francia. University of Pennsylvania Press. (2001) 
Bernard S. Bachrach, "Some observations on the origins of the Angevin dynasty", Medieval Prosopography 10 no. 2 (1989): 1-24.
Christian Settipani, "Les comtes d'Anjou et leur alliances aux Xe et XIe siècles", in K. S. B. Keats-Rohan, ed., Family Trees and the Roots of Politics (Woodbridge, Suffolk, 1997): 211-267.
Greg Halfond, "Review of La Noblesse du Midi carolingien: Études sur quelques grandes familles d'Aquitaine et du Languedoc du IXe au XIe siècles, Toulousain, Périgord, Limousin, Poitou, Auvergne. Prosopographica et Genealogica", in the Medieval Review. vol. 5. pp. 388.
Nathaniel L. Taylor, "Roman Genealogical Continuity and the 'Descents-from-Antiquity' Question. A Review Article" in The American Genealogist 76 (2001), 129-136. 
Martin Heinzelmann, Gregory of Tours: History and Society in the Sixth Century. Cambridge University Press, (2001) 
Karl Ferdinand Werner, "L'apport de la prosopographie à l'histoire sociale des élites", in K.S.B. Keats-Rohan ed., Family Trees and the Roots of Politics. Woodbridge, (1997), 1-21.
Beech, George, Review of La Noblesse du Midi carolingien: Études sur quelques grandes familles d'Aquitaine et du Languedoc du IXe au XIe siècles, Toulousain, Périgord, Limousin, Poitou, Auvergne. Prosopographica et Genealogica", in Medieval Prosopography, Vol. 25 (2004) pp. 235–236