Chromosome 10 (human)

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Chromosome 10 (human)
Human male karyotpe high resolution - Chromosome 10 cropped.png
Human chromosome 10 pair after G-banding.
One is from mother, one is from father.
Human male karyotpe high resolution - Chromosome 10.png
Chromosome 10 pair in human male karyogram.
Length (bp) 133,797,422 bp[1]
No. of genes 2,174[2]
Type Autosome
Centromere position Submetacentric[4]
RefSeq NC_000010
GenBank CM000672
Map of Chromosome 10
Ideogram. For band names, see locus.

Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies. In January 2017, two estimates differed by 13%, with one estimate giving 2,174[2] genes, and the other estimate giving 1,899[3] genes.


The following are some of the genes located on chromosome 10:

  • ALOX5: Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response; also facilitates development and maintenance of cancer stem cells, slow-dividing cells thought to give rise to a variety of cancers, including leukemia)
  • ARID5B: encoding protein AT-rich interactive domain-containing protein 5B
  • AS3MT: encoding enzyme Arsenite methyltransferase
  • AVPI1: encoding protein Arginine vasopressin-induced protein 1
  • C10orf118: encoding protein Uncharacterized protein C10orf118
  • CAMK1D: calcium/calmodulin-dependent protein kinase ID
  • CDH23: cadherin-like 23
  • CXCL12: chemokine (C-X-C motif) ligand 12, SDF-1, scyb12
  • EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
  • ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
  • FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome)
  • HELLS: Lymphoid-specific helicase
  • PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
  • PCDH15: protocadherin 15
  • PTEN gene: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
  • RET: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
  • UROS: uroporphyrinogen III synthase (congenital erythropoietic porphyria)
  • PROSER2: proline and serine rich 2 or c10orf47

Diseases and disorders[edit]

The following diseases are related to genes on chromosome 10:


  1. ^ "Human Genome Assembly GRCh38.p10 - Genome Reference Consortium". National Center for Biotechnology Information. 2017-01-06. Retrieved 2017-03-04. 
  2. ^ a b "Homo sapiens (human) Chromosome 10". NCBI Map Viewer. National Center for Biotechnology Information. Retrieved January 20, 2017. 
  3. ^ a b "Homo sapiens: Chromosome summary: Chromosome 10:1-133797422". Wellcome Trust Sanger Institute. Vega Genome Browser 58. Retrieved January 20, 2017. 
  4. ^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999. 
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  • Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet. 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438. 
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