Chromosome 14 (human)

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Chromosome 14 (human)
Human male karyotpe high resolution - Chromosome 14 cropped.png
Pair of human chromosome 14 (after G-banding).
One is from mother, one is from father.
Human male karyotpe high resolution - Chromosome 14.png
Chromosome 14 pair in human male karyogram.
Features
Length (bp) 107,043,718 bp
Number of genes 2,055[1]
1,894[2]
Type Autosome
Centromere position Acrocentric[3]
Identifiers
RefSeq NC_000014
GenBank CM000676
Map of Chromosome 14
Ideogram of human chromosome 14. Mbp means mega base pair. See locus for other notation.

Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 107 million base pairs (the building material of DNA) and represents between 3 and 3.5% of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies. In January 2017, two estimates differed by 9%, with one estimate giving 2,055[1] genes, and the other estimate giving 1,894[2] genes.

The centromere of chromosome 14 is positioned approximately at position 19.0-19.1 Mbp.

Genes[edit]

The following are some of the genes located on chromosome 14:

Diseases and disorders[edit]

The following diseases are some of those related to genes on chromosome 14:

References[edit]

  1. ^ a b "Homo sapiens (human) Chromosome 16". NCBI Map Viewer. National Center for Biotechnology Information. Retrieved January 20, 2017. 
  2. ^ a b "Homo sapiens: Chromosome summary: Chromosome 14:1-107043718". Wellcome Trust Sanger Institute. Vega Genome Browser 58. Retrieved January 20, 2017. 
  3. ^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999. 
  4. ^ Quiat D, Voelker KA, Pei J, Grishin NV, Grange RW, Bassel-Duby R, Olson EN (June 2011). "Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6". Proc. Natl. Acad. Sci. U.S.A. 108 (25): 10196–201. doi:10.1073/pnas.1107413108. PMC 3121857Freely accessible. PMID 21633012. 
  • Campo E (2003). "Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma". Hum Pathol. 34 (4): 330–5. doi:10.1053/hupa.2003.97. PMID 12733111. 
  • Gilbert F (1999). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 14". Genet Test. 3 (4): 379–91. PMID 10627948. 
  • Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
  • Kamnasaran D, Cox DW (2002). "Current status of human chromosome 14". J Med Genet. 39 (2): 81–90. doi:10.1136/jmg.39.2.81. PMC 1735028Freely accessible. PMID 11836355. 
  • Lemire EG, Cardwell S (1999). "Unusual phenotype in partial trisomy 14". Am J Med Genet. 87 (4): 294–6. doi:10.1002/(SICI)1096-8628(19991203)87:4<294::AID-AJMG2>3.0.CO;2-S. PMID 10588832. 
  • van Karnebeek CD, Quik S, Sluijter S, Hulsbeek MM, Hoovers JM, Hennekam RC (2002). "Further delineation of the chromosome 14q terminal deletion syndrome". Am J Med Genet. 110 (1): 65–72. doi:10.1002/ajmg.10207. PMID 12116274.