Chromosome 16 (human)
|Chromosome 16 (human)|
Pair of human chromosome 16 (after G-banding).
One is from mother, one is from father.
Chromosome 16 pair in human male karyogram.
|Length (bp)||90,338,345 bp|
|Number of genes||1,535|
|Centromere position||Metacentric |
Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 16 probably contains between 850 and 1,200 genes.
In February 2010, a new cause of obesity due to a microdeletion on chromosome 16 was announced. It may explain about 1% of obesity cases. This research was carried out by Professor Froguel, a CNRS researcher, in Lille, and others at Imperial College in London and Vaudois University and was published in Nature on February 4, 2010. This defect was identified using DNA microarrays and it leads to the suppression of about thirty genes in one region of chromosome 16. Research showed that this microdeletion is relatively common in obese people but lacking in most non-obese people.
Diseases and Disorders
- Trisomy 16
- Familial Mediterranean fever (FMF)
- Crohn's disease
- Autosomal dominant polycystic kidney disease (PKD-1)
- "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999.
- McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, Zackai EH, Kaplan P, Ganesh J, Krantz ID, Spinner NB, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee YH, Vacic V, Gary S, Iakoucheva LM, Crow TJ, Christian SL, Lieberman JA, Stroup TS, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour VL, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon FJ, Malhotra AK, Potash JB, Schulze TG, Nöthen MM, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere CM, Sutcliffe JS, Skuse D, Gill M, Gallagher L, Mendell NR, Craddock N, Owen MJ, O'Donovan MC, Shaikh TH, Susser E, Delisi LE, Sullivan PF, Deutsch CK, Rapoport J, Levy DL, King MC, Sebat J (November 2009). "Microduplications of 16p11.2 are associated with schizophrenia". Nat. Genet. 41 (11): 1223–7. doi:10.1038/ng.474. PMC 2951180. PMID 19855392.
- Gilbert F (1999). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 16". Genet Test 3 (2): 243–54. PMID 10464676.
- Martin J, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
- Miller, David T; Nasir, Ramzi; Sobeih, Magdi M; Shen, Yiping; Wu, Bai-Lin; Hanson, Ellen (2011-10-27). 16p11.2 Microdeletion. PMID 20301775. NBK11167. In Pagon RA, Bird TD, Dolan CR; et al., eds. (1993). GeneReviews™ [Internet]. Seattle WA: University of Washington, Seattle.
|Wikimedia Commons has media related to Human chromosome 16.|
|This genetics article is a stub. You can help Wikipedia by expanding it.|