Chromosome 3 (human)

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Chromosome 3 (human)
Human male karyotpe high resolution - Chromosome 3 cropped.png
Human chromosome 3 pair after G-banding. One is from mother, one is from father.
Human male karyotpe high resolution - Chromosome 3.png
Chromosome 3 pair in human male karyogram.
Length (bp) 198,295,559 bp[1]
No. of genes 2,971[2]
Type Autosome
Centromere position Metacentric[4]
RefSeq NC_000003
GenBank CM000665
Map of Chromosome 3
Ideogram. For band names, see locus.

Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans almost 200 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies. In January 2017, two estimates differed by 16%, with one estimate giving 2,971[2] genes, and the other estimate giving 2,565[3] genes.


The following are some of the genes located on chromosome 3:

  • AMOTL2: encoding protein]] Angiomotin-like protein 2
  • APEH: encoding enzyme Acylamino-acid-releasing enzyme
  • AZI2: encoding protein 5-azacytidine-induced protein 2
  • C3orf23: encoding protein Uncharacterized protein C3orf23
  • C3orf60/NDUFAF3: encoding enzyme NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
  • C3orf70: encoding protein C3orf70 (Chromosome 3 Open Reading Frame 70)



  • ADIPOQ: adiponectin
  • CAMPD1: Camptodactyly
  • CPOX: coproporphyrinogen oxidase (coproporphyria, harderoporphyria)
  • HGD: homogentisate 1,2-dioxygenase (homogentisate oxidase)
  • IFT122: intraflagellar transport gene 122
  • MCCC1: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
  • PCCB: propionyl Coenzyme A carboxylase, beta polypeptide
  • PDCD10: programmed cell death 10
  • PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • RAB7: RAB7, member RAS oncogene family
  • RHO: rhodopsin visual pigment
  • SOX2: transcription factor
  • USH3A: Usher syndrome 3A
  • ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

Diseases and disorders[edit]

The following diseases and disorders are some of those related to genes on chromosome 3:


  1. ^ "Human Genome Assembly GRCh38.p10 - Genome Reference Consortium". National Center for Biotechnology Information. 2017-01-06. Retrieved 2017-03-04. 
  2. ^ a b "Homo sapiens (human) Chromosome 3". NCBI Map Viewer. National Center for Biotechnology Information. Retrieved January 20, 2017. 
  3. ^ a b "Homo sapiens: Chromosome summary: Chromosome: 3:1-198295559". Wellcome Trust Sanger Institute. Vega Genome Browser 58. Retrieved January 20, 2017. 
  4. ^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999. 
  5. ^ CRBN cereblon [Homo sapiens (human)] - Gene - NCBI