Chronic allograft nephropathy

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Chronic allograft nephropathy
Chronic allograft nephropathy - intermed mag.jpg
Micrograph of chronic allograft nephropathy. PAS stain.
Classification and external resources
Specialty urology

Chronic allograft nephropathy, abbreviated CAN and also known as sclerosing/chronic allograft nephropathy, is the leading cause of kidney transplant failure[1] and happens month to years after the transplant.


CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.[2]


CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.


The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.[2][3]


  1. ^ Paul, LC. (Sep 1999). "Chronic allograft nephropathy: An update". Kidney Int. 56 (3): 783–93. doi:10.1046/j.1523-1755.1999.00611.x. PMID 10469349.
  2. ^ a b Joosten, SA.; Sijpkens, YW.; van Kooten, C.; Paul, LC. (Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations". Kidney Int. 68 (1): 1–13. doi:10.1111/j.1523-1755.2005.00376.x. PMID 15954891.
  3. ^ Nankivell, BJ.; Chapman, JR. (Mar 2006). "Chronic allograft nephropathy: current concepts and future directions". Transplantation. 81 (5): 643–54. doi:10.1097/ PMID 16534463.