Chronic eosinophilic leukemia

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Chronic eosinophilic leukemia

Chronic eosinophilic leukemia (CEL) is a disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. CEL may stay the same for many years, or it may progress quickly to acute leukemia. It is generally caused by overactivation of the oncogene, e.g. PDGFRA through a chromosome translocation or fusion between two genes on the same chromosome, e.g. FIP1L1-PDGFRA gene fusion-induced eosinophilic leukemia.[1] Though a highly rare disease, CEL is extremely manageable with the use of Gleevec, which suppresses the oncogenic effects of PDGFRA.


  1. ^ Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704–714. doi:10.1182/blood-2016-10-695973. PMID 28028030.

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 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".