Chronic functional abdominal pain

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Chronic functional abdominal pain (CFAP) or Functional abdominal pain syndrome (FAPS)[1] is the ongoing presence of abdominal pain for which there is no known medical explanation. It is quite similar to, but less common than, irritable bowel syndrome (IBS), and many of the same treatments for IBS can also be of benefit to those with CFAP. The fundamental difference between IBS and CFAP is that in CFAP, unlike in IBS, there is no change in bowel habits such as constipation or diarrhea. Bowel dysfunction is a necessary diagnostic criterion of IBS.

CFAP is characterized by chronic pain, with no physical explanation or findings (no structural, infectious, or mechanical causes can be found). It is theorized that CFAP is a disorder of the nervous system where normal nociceptive nerve impulses are amplified "like a stereo system turned up too loud" resulting in pain. Alternately it is hypothesized that there exists in the intestine a protozoan (namely blastocystis) which is interacting with the sympathetic nervous system and causing the pain. Newer semi-synthetic antibiotics such as rifaximin have been used in treatment. This visceral hypersensitivity may be a stand-alone cause of CFAP, or CFAP may result from the same type of brain-gut nervous system disorder that underlies IBS. As with IBS, low doses of antidepressants have been found useful in controlling the pain of CFAP.[2]


  1. ^ Clouse, RE; Mayer, EA; Aziz, Q; Drossman, DA; et al. (2006). "Functional abdominal pain syndrome". Gastroenterology 130 (5): 1492–7. doi:10.1053/j.gastro.2005.11.062. PMID 16678562. 
  2. ^ Drossman, DA (2013). "Functional abdominal pain syndrome". Milwaukee, WI: International Foundation for Functional Gastrointestinal Disorders. 

Further reading[edit]

External links[edit]