Chronotherapy (treatment scheduling)

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"Chronotherapy" redirects here. For other uses, see Chronotherapy (sleep phase).
Chronotherapy (treatment scheduling)
MeSH D019454

Chronotherapy, also called chronotherapeutics[1] or chronotherapeutic drug delivery,[2] refers to the use of circadian or other rhythmic cycles of a condition's symptoms and/or of the individual being treated in the application of therapy.[2] Examples of this are treatments of psychiatric and somatic diseases that are administered according to a schedule that corresponds to these rhythms in order to maximize effectiveness and minimize side effects of the therapy.[3]

Chronotherapy is used in various clinical fields such as the treatments of asthma,[4][5] cancer, hypertension,[6] and multiple types of depression, among others seasonal affective disorder and bipolar disorder.

Chronotherapy is also becoming increasingly popular in non-clinical settings, for example on the work floor, where it is used to increase productivity and performance.[citation needed]

Methods of chronotherapy[edit]

Methods of pharmaceutical chronotherapy[edit]

  • Imitative/Mimetic: Imitating the natural changes in a certain substance in the body.
  • Preventive/Precautionary: Taking medicines at the moment that they are most necessary, for example taking hypertension medicine at the time of day that the blood pressure is rising.
  • Wake therapy

See also[edit]


  1. ^ "Medical dictionary". Merriam-Webster. Retrieved 6 January 2017. 
  2. ^ a b Sajan, J (October 2009). "Chronotherapeutics and Chronotherapeutic Drug Delivery Systems". Tropical Journal of Pharmaceutical Research. 8 (5): 467–475. doi:10.4314/tjpr.v8i5.48091. ISSN 1596-5996. Retrieved 6 January 2017. ...drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. 
  3. ^ "Dictionary Definition". 
  4. ^ "Chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy". Journal of Allergy and Clinical Immunology. 95: 1172–1178. doi:10.1016/S0091-6749(95)70073-0. 
  5. ^ "Further studies on the chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy". Journal of Allergy and Clinical Immunology. 100: 771–774. doi:10.1016/S0091-6749(97)70272-0. 
  6. ^ "Circadian variation of blood pressure: The basis for the chronotherapy of sleeping disorders, hypertension". Advanced Drug Delivery Reviews. 59 (9–10): 904–922. doi:10.1016/j.addr.2006.08.003.