Chronotherapy (treatment scheduling)

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Chronotherapy (treatment scheduling)

Chronotherapy, also called chronotherapeutics[1] or chronotherapeutic drug delivery,[2] refers to the use of circadian or other rhythmic cycles of a condition's symptoms and/or of the individual being treated in the application of therapy.[2] Examples of this are treatments of psychiatric and somatic diseases that are administered according to a schedule that corresponds to these rhythms in order to maximize effectiveness and minimize side effects of the therapy.[3]

Chronotherapy is used in various clinical fields such as the treatments of asthma,[4][5][non-primary source needed] cancer,

hypertension,[6] seasonal affective disorder

and bipolar disorder


In the treatment of psychiatric conditions including bipolar depression[7][8], a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.[9][10][11]



  1. ^ "Medical dictionary". Merriam-Webster. Retrieved 6 January 2017.
  2. ^ a b Sajan J (October 2009). "Chronotherapeutics and Chronotherapeutic Drug Delivery Systems". Tropical Journal of Pharmaceutical Research. 8 (5): 467–475. doi:10.4314/tjpr.v8i5.48091. ISSN 1596-5996. Retrieved 6 January 2017. ...drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects.
  3. ^ "Dictionary Definition".
  4. ^ Pincus DJ, Szefler SJ, Ackerson LM, Martin RJ (June 1995). "Chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 95 (6): 1172–8. doi:10.1016/S0091-6749(95)70073-0. PMID 7797785.
  5. ^ Pincus DJ, Humeston TR, Martin RJ (December 1997). "Further studies on the chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 100 (6 Pt 1): 771–4. doi:10.1016/S0091-6749(97)70272-0. PMID 9438485.
  6. ^ Hermida RC, Ayala DE, Portaluppi F (August 2007). "Circadian variation of blood pressure: the basis for the chronotherapy of hypertension". Advanced Drug Delivery Reviews. 59 (9–10): 904–22. doi:10.1016/j.addr.2006.08.003. PMID 17659807.
  7. ^ Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates". The Journal of Clinical Psychiatry. 66 (12): 1535–40. PMID 16401154.
  8. ^ Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression". The Journal of Clinical Psychiatry. 75 (2): 133–40. doi:10.4088/JCP.13m08455. PMID 24345382.
  9. ^ Benedetti F, Barbini B, Colombo C, Smeraldi E (December 2007). "Chronotherapeutics in a psychiatric ward". Sleep Medicine Reviews. 11 (6): 509–22. doi:10.1016/j.smrv.2007.06.004. PMID 17689120.
  10. ^ Benedetti F (December 2012). "Antidepressant chronotherapeutics for bipolar depression". Dialogues in Clinical Neuroscience. 14 (4): 401–11. PMC 3553570. PMID 23393416.
  11. ^ Dallaspezia S, Suzuki M, Benedetti F (December 2015). "Chronobiological Therapy for Mood Disorders". Current Psychiatry Reports. 17 (12): 95. doi:10.1007/s11920-015-0633-6. PMID 26478195.