Chymopapain

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Chymopapain
1yal.jpg
Chymopapain's structure
Identifiers
EC number 3.4.22.6
CAS number 2593837
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Chymopapain
Clinical data
Legal status
  • (Prescription only)
Routes of
administration
Injection into intervertebral disc
Identifiers
CAS Registry Number  YesY
ATC code M09AB01
UNII 1UK146T40N YesY
ChEMBL CHEMBL1201626 N
 N (what is this?)  (verify)

Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis.

The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing it decided to stop selling worldwide.[2][3]

Side effects[edit]

Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death.[4]

See also[edit]

References[edit]

  1. ^ Chymopapain Injection from MedicineNet
  2. ^ http://www.mayoclinic.com/health/drug-information/DR600373
  3. ^ The Current Status of Chymopapain
  4. ^ http://www.mayoclinic.com/health/drug-information/DR600373

External links[edit]