Cicletanine

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Cicletanine
Cycletanine.png
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Protein binding97.3%
Elimination half-life7.9 h
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.158.583 Edit this at Wikidata
Chemical and physical data
FormulaC14H12ClNO2
Molar mass261.703 g/mol g·mol−1
3D model (JSmol)
  (verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.[2]

Mechanism[edit]

It can inhibit protein kinase C.[3]

References[edit]

  1. ^ Jean Sassard (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 978-0-86196-313-3.
  2. ^ Bagrov AY; Dmitrieva RI; Dorofeeva NA; et al. (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". J. Hypertens. 18 (2): 209–15. doi:10.1097/00004872-200018020-00012. PMID 10694190.
  3. ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension. 41 (3): 505–11. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951.

External links[edit]