Ciclotizolam

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Ciclotizolam
Ciclotizolam structure.svg
Ball-and-stick model of the ciclotizolam molecule
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C20H18BrClN4S
Molar mass 461.806 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Ciclotizolam[1] (WE-973) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.[2][3]

See also[edit]

References[edit]

  1. ^ DE Patent 2445430
  2. ^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology. 109 (1): 19–31. PMID 2986988. doi:10.1016/0014-2999(85)90535-7. 
  3. ^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences. 45 (4): 349–58. PMID 2569655. doi:10.1016/0024-3205(89)90145-8.