The Western Lancet was founded as a monthly journal in 1842 with L. M. Lawson as its founding editor; it was one of the earliest medical journals in Cincinnati, Ohio. In 1858, it merged with the Medical Observer (founded 1856), under the title of the Cincinnati Lancet and Observer. In 1873, J. C. Culbertson purchased the journal.
The Clinic was founded in 1871 as a weekly journal by the faculty of the Medical College of Ohio. J. C. Culbertson gained control over it in 1878, and merged it with the Cincinnati Lancet and Observer, forming a combined weekly journal, the Cincinnati Lancet and Clinic, of which he and James G. Hyndman were the initial editors. It was renamed to the hyphenated Lancet-Clinic in 1888.
The journal ceased publication in November 1916, citing financial difficulties.
- David A. Tucker, Jr. (1948). "The Cincinnati Lancet-Clinic". Ohio State Archaeological and Historical Quarterly. 57: 387–392.