Cirsium ochrocentrum is a species of thistle known by the common name yellowspine thistle. It is native to the Great Plains of the Central United States and to the desert regions of the western United States and northern Mexico. Its range extends from eastern Oregon east to the Black Hills of South Dakota, south as far as the Mexican State of Durango.
The plant is a perennial herb growing up to 1 metre (3.3 ft) tall, with one to twenty white woolly stems per plant.
The leaves are generally deeply lobed and the lobes cut into sharp teeth. The longest leaves at the base of the plant are up to about 25 centimeters (10 inches) long. The leaves are spiny, with spines up to 1.5 centimeters long. 
- Cirsium ochrocentrum var. martinii (Barlow-Irick) D.J.Keil - Mexico, Arizona, New Mexico
- Cirsium ochrocentrum var. ochrocentrum - United States
Among the Zuni people, an infusion of the plant taken by both partners as a contraceptive. An infusion of whole plant is also taken as a diaphoretic, diuretic, and emetic to treat syphilis. An infusion of the fresh or dried root is taken three times a day for diabetes.
- The Plant List, Cirsium ochrocentrum A.Gray
- Biota of North America Program 2014 county distribution map
- Flora of North America, Cirsium ochrocentrum A. Gray
- CalFlora taxon report, University of California: Cirsium ochrocentrum
- Flora of North America
- Camazine, Scott and Robert A. Bye 1980 A Study Of The Medical Ethnobotany Of The Zuni Indians of New Mexico. Journal of Ethnopharmacology 2:365-388 (p.374)
- Stevenson, Matilda Coxe 1915 Ethnobotany of the Zuni Indians. SI-BAE Annual Report #30 (p.44-45)
- United States Department of Agriculture Plants Profile of Cirsium ochrocentrum (yellowspine thistle)
- Cirsium ochrocentrum —CalPhotos photo gallery, University of California
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