Clara D. Bloomfield

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Clara Derber Bloomfield
BornMay 15, 1942 (1942-05-15) (age 76)
Flushing, New York
Spouse(s)Albert de la Chapelle

Clara D. Bloomfield (born May 15, 1942 in Flushing, New York), is an American physician and cancer researcher. Her work has focused on the genetic changes that are present in certain types of blood cancers, and how those can be utilized to improve treatment for the affected patients.



Bloomfield earned her B.A. from the San Diego State College, San Diego, California in 1963 and her M.D. from the University of Chicago in 1968. She completed a residency in internal medicine at the University of Chicago and a fellowship in medical oncology at the University of Minnesota.

Professional career[edit]

Bloomfield was the first woman to reach the rank of a full professor of medicine at the University of Minnesota in 1980. In 1989, she became professor of medicine and chief of the Division of Oncology at the State University of New York at Buffalo. At the same time, she was chair of the Division of Medicine at Roswell Park Cancer Institute.

In 1997, she moved to Columbus, Ohio, where she became director of the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James). She held this position until 2003.

Bloomfield is a distinguished university professor and senior adviser at the OSUCCC-James. She is also a member of the Molecular Biology and Cancer Genetics Program, a professor of internal medicine, and she holds the William Greenville Pace III Endowed Chair in Cancer Research.


Early in her career, Bloomfield focused on the study of chromosome abnormalities in cancers of the hematopoietic system (leukemias and lymphomas). She and her co-workers identified several novel chromosome changes in leukemia and lymphoma, and discovered that these abnormalities are among the most important factors that determine a patient's prognosis. For example, Dr Bloomfield was involved in the discovery of the Philadelphia chromosome in patients with acute lymphoblastic leukemia (ALL).[1] She was also involved in describing the rearrangement of chromosome 16q22 in acute myeloid leukemia.

More recently, her work has focused on molecular changes (gene mutations and deregulated expression of genes and microRNAs) that occur in adults with acute myeloid leukemia. Bloomfield has published more than 400 publications in peer-reviewed scientific journals.

Bloomfield is a co-author of the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues,[2] and the European LeukemiaNet (ELN) guidelines on diagnosis and management of acute myeloid leukemia.[3]

Personal life[edit]

Bloomfield is married to Albert de la Chapelle, a geneticist and professor in the Department of Molecular Virology, Immunology and Medical Genetics at The Ohio State University and discoverer of XX male syndrome.

Honors and awards[edit]

Bloomfield was elected a member of the Institute of Medicine of the National Academy of Sciences in 2000. In 2011, she was elected as a fellow of the American Academy of Arts and Sciences. She also is an elected member of the Association of American Physicians and an elected fellow of the American Association for the Advancement of Science.

Among the awards Bloomfield received during her career are:



  1. ^ Bloomfield, CD; Peterson, LC; Yunis, JJ; Brunning, RD (1977). "The Philadelphia chromosome (Ph1) in adults presenting with acute leukaemia: A comparison of Ph1+ and Ph1-patients". British Journal of Haematology. 36 (3): 347–58. doi:10.1111/j.1365-2141.1977.tb00658.x. PMID 268208.
  2. ^ The International Agency for Research on Cancer (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (4th ed.). World Health Organization. p. 441. ISBN 978-92-832-2431-0.
  3. ^ Dohner, H.; Estey, E. H.; Amadori, S.; Appelbaum, F. R.; Buchner, T.; Burnett, A. K.; Dombret, H.; Fenaux, P.; et al. (2009). "Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–74. doi:10.1182/blood-2009-07-235358. PMID 19880497.
  4. ^ AACR Joseph H. Burchenal Clinical Research Award Winners Archived 2012-04-27 at the Wayback Machine.
  5. ^ Henry M. Stratton Medal recipients
  6. ^ Making Strides toward “Curing the Incurable”: Karnofsky Award Winner, Dr. Clara Bloomfield, Honored for Practice-changing Leukemia, Lymphoma Research

External links[edit]