Humphrey's stellar career included being named First-team All-Pro five times (1971-'74, and 1977), Second- Team All-Pro three times (1969, 1970, 1976), and All-NFC six times (1970-'74, 1977). He was Second-Team All-NFC in 1976 when Humphrey unofficially recorded a career high 15 quarterback sacks. In addition Humphrey was named to the Pro Bowl six times over the span of his career (1970-'74 & 1977).
Humphrey finished out his career with the Philadelphia Eagles from 1979-'81. In 1980 Humphrey enjoyed a stellar season as a designated pass rusher, recording a team high 14½ sacks helping the Eagles become NFC Champions and earn a ticket to Super Bowl XV. He finished his career with 126½ career sacks with the Falcons and Eagles.
During the Super Bowl XV highlight film, Humphrey was witnessed throwing a penalty flag at referee Ben Dreith after Dreith flagged Humphrey for roughing Oakland Raiders quarterback Jim Plunkett.
Humphrey is a member of the Georgia Hall of Fame and the Tennessee Hall of Fame. His college (Tennessee State University) retired his number and inducted him into their Hall of Fame. His high school has also retired his jersey and he is a member of his high school Hall of Fame, and is a member of the Atlanta Falcons Ring of Honor.
Humphrey was a final 15 candidate in 2003, 2005, and 2006. On August 27, 2008, he was named as one of two senior candidates for the 2009 Hall of Fame election. In August 2013, he was named as one of two senior candidates for the 2014 Hall of Fame election.
In February 2014, Claude Humphrey was elected to the NFL Hall of Fame on the senior ballot. During his time in football, Mr. Humphrey was a revolutionary pass rushing defensive lineman who paved the way for Reggie White, Bruce Smith, and fellow 2014 NFL HOF inductee Michael Strahan.
On August 2, 2014, Humphrey was officially inducted at the Enshrienment Ceremony where his bust, sculpted by Scott Myers, was unveiled.