George Clayton Stapleton (June 24, 1921 – October 30, 2014) was an American football player, coach, and college athletics administrator. He was the 23rd head football coach for the Iowa State University Cyclones located in Ames, Iowa, and held that position for ten seasons, from 1958 until 1967. His career coaching record at Iowa state was 42 wins, 53 losses, and 4 ties. This ranks him second at Iowa state in total wins and 17th at Iowa state in winning percentage.
On September 9, 2006, Stapleton was inducted into the Iowa State Athletics Hall of Fame with fellow alumni Beth Bader, Jon Brown, John Crawford, Barry Hill, Russ Hoffman, Jerry McNertney, Hugo Otopalik, Keith Sims, and Winnifred Tilden.