Clear-cell ovarian carcinoma

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Micrograph of an ovarian clear cell carcinoma. H&E stain.

Clear cell ovarian tumors are part of the surface epithelial-stromal tumor group of ovarian cancers, accounting for 6% of these cancers. Clear cell tumors are also associated with the pancreas and salivary glands.


Typically, they are cystic neoplasms with polypoid masses that protrude into the cyst. On microscopic pathological examination, they are composed of cells with clear cytoplasm (that contains glycogen) and hob nail cells (from which the glycogen has been secreted). The pattern may be glandular, papillary or solid.


Benign and borderline variants of this neoplasm are rare, and most cases are malignant. These tumors may have a worse prognosis than serous tumors.[1]


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