Clifton is a Census-designated place located in Spartanburg County in the U.S. State of South Carolina. According to the 2010 United States Census, the population was 541.
Clifton is located at 34°59′10″N 81°49′13″W / 34.98611°N 81.82028°W (34.986051, -81.820395). These coordinates place the CDP on the East side of the county, between the cities of Spartanburg and Cowpens.
According to the United States Census Bureau, the CDP has a total land area of 1.073 square miles (2.946 km²) and a total water area of 0.065 square miles (0.168 km²).